Imipenem/Cilastatin-Associated Hiccups

Lucena, M. Isabel; Andrade, R.J.; Cabello, María Isabel Egocheaga; Clavijo, E; E, Queipo de Llano

doi:10.1177/106002809202601125

Cited by 6 publications

(3 citation statements)

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“…Few well reported cases of antibiotic-induced hiccups were published (Table 1). [2][3][4][5][6][7][8][9] All of the reported cases were of male patients. The male gender seems to be an independent risk factor for drug-induced hiccups as mentioned by Hosoya et al 10 The age varies from 10 to 76 years.…”

Section: Discussionmentioning

confidence: 99%

“…Cephalosporins are believed to exert an inhibitory effect on gamma-aminobutyric acid transmission of cortical pyramidal cells due to their beta-lactam ring structure, which shares similar molecular architecture to that of GABA neurotransmitters. 9 Neurotoxicity is attributed to their ability to cross the blood-brain barrier and produce gamma-aminobutyric acid antagonism. The possible mechanism of hiccups in our case appears to involve gamma-aminobutyric acid receptor inhibition rather than a dopamine interaction, although other mechanisms may be possible.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic-Induced Hiccups: A Case Report and Brief Literature Review

Barka,

Abdesslem,

Jarrar

et al. 2023

Hosp Pharm

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Hiccups, also called hiccoughs, are sudden, involuntary and rapid expulsion of air from the lungs with synchronous closure of the glottis causing blockade of the air flow. Hiccups may be induced by a multitude of etiologies such as central nervous disorders, gastrointestinal disorders, cardiovascular disorders, psychogenic factors, and metabolic disorders. Hiccups induced by medications are rare. The diagnosis of drug-induced hiccup is difficult. The exact mechanism responsible for this adverse drug reaction is still unknown. Herein, we report the first case of cefotaxime-induced hiccups and briefly review the literature on antibiotic-induced hiccups.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibiotic-Induced Hiccups: A Case Report and Brief Literature Review

Barka,

Abdesslem,

Jarrar

et al. 2023

Hosp Pharm

View full text Add to dashboard Cite

show abstract

“…A positive recurrence on exposure was demonstrated. Other published case reports have involved cephalosporins [cefotetan (4), ceftriaxone (5)], imipenem (6) and doxycycline (7)].…”

Section: Discussionmentioning

confidence: 99%