Iminodiacetic Acid Derivatives

Smith, Robert M.; Martell, Arthur E.

doi:10.1007/978-1-4615-6764-6_2

Cited by 4 publications

(4 citation statements)

References 264 publications

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“…Ac 3+ stability constants are similar to those of La 3+ , but usually slightly lower. [60][61][62][63]66,67 The smaller Ac 3+ stability constants are a consequence of the large radius of this ion, which gives rise to weaker electrostatic interactions with the ligand donor atoms.…”

Section: Coordination Chemistrymentioning

confidence: 99%

Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches

Thiele

Wilson

2018

Cancer Biotherapy and Radiopharmaceuticals

104

114

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The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle emissions to destroy tumors. A key factor, however, that may hinder the clinical use of actinium-225 is the poor understanding of its coordination chemistry, which creates challenges for the development of suitable chelation strategies for this ion. In this article, we provide an overview of the known chemistry of actinium and a summary of the chelating agents that have been explored for use in actinium-225-based TAT. This overview provides a starting point for researchers in the field of TAT to gain an understanding of this valuable therapeutic radionuclide.

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Section: Coordination Chemistrymentioning

confidence: 99%

Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches

Thiele

Wilson

2018

Cancer Biotherapy and Radiopharmaceuticals

104

114

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“…All procedural instructions are given in the hardness determination standard as well as in the Supporting Information. In the titration of the digested residue (III), cyclohexanediaminetetraacetic acid, disodium magnesium trihydrate saltalso known as magnesium salt of CDTA (CAS 63451-33-2, Hach Company, Inc.)was used to obtain a distinct end point in the presence of possible interference from other metal ions. ,, …”

Section: Experimental Sectionmentioning

confidence: 71%

“…In the titration of the digested residue (III), cyclohexanediaminetetraacetic acid, disodium magnesium trihydrate saltalso known as magnesium salt of CDTA (CAS 63451-33-2, Hach Company, Inc.)was used to obtain a distinct end point in the presence of possible interference from other metal ions. 25,26,35 Determination of MgOHCl and MgO. By leveraging the physical and chemical separations shown in Scheme 1, the determination of Mg 2+ content can be used to calculate the MgOHCl and MgO present in the starting sample.…”

Section: Analytical Chemistrymentioning

confidence: 99%

“…8 The method has been evaluated for accuracy and consistency with MgOHCl concentration in the range of 0.3−9.0 wt % as shown in Figure 6 with the commercial carnallite supplied by ICL. On the basis of recent efforts, 35 where a higher purity commercial carnallite and an improved salt purification process were used, 0.11 ± 0.02 wt % of MgOHCl was measured (based on more than 10 samples) using a more diluted EDTA solution (i.e., 5× more diluted than the original 0.0250 M given in the Experimental Section). Therefore, based on our experimental results, a level of MgOHCl can be confidently measured down to ∼0.1 wt %.…”

Section: E N Nmentioning

confidence: 99%

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Method To Determine MgO and MgOHCl in Chloride Molten Salts

et al. 2020

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A commercial blend of mainly carnallite (KCl·MgCl2·6H2O) is considered as a next-generation heat transfer fluid in solar thermal plants. Corrosive properties of MgCl2 hydrates must be addressed at the operating temperatures of 500–720 °C. For successful chemical monitoring of the carnallite heat transfer fluid, an experimental method was developed to separate and titrate for MgO and MgOHCl from solid carnallite. This new method was assessed for error and accuracy. The method’s relative error for MgOHCl was −7.0% for a mass fraction of 9.0 wt % MgOHCl in the carnallite salt. The method’s relative error for MgO was less than +1.0% for a mass fraction of 12.0 wt % MgO in the carnallite salt. Titration results were used to track changes in the MgOHCl concentration in carnallite salt through the carnallite’s dehydration and purification.

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An original structural fold underlies the multitask P1, a silencing suppressor encoded by the Rice yellow mottle virus

Poignavent

Hoh

Terral

et al. 2020

Preprint

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The Rice Yellow Mottle sobemovirus (RYMV) belongs to the most damaging pathogens devastating rice fields in Africa. P1, a key protein for RYMV, was reported as a potent RNAi suppressor counteracting RNA silencing in plant reporter systems. Here we describe the complete 3D structure and dynamics of P1. Its N-terminal region contains ZnF1, a structural CCCC-type zinc finger strongly affine to zinc and a prominent short helix, rendering this region poorly amenable to structural changes. P1 C-terminal region contains ZnF2, an atypical HCHC-type ZnF that does not belong to any existing class of Zn finger proteins. ZnF2 appeared much less affine to zinc and more sensitive to oxidizing environments than ZnF1, and may serve as a sensor of plant redox status. We also identified key residues essential for RYMV infectivity and spread in rice tissues through their participation in P1 oligomerization and folding.Altogether, our results provide the first complete structure of a rice antiviral silencing suppressor and highlight P1 structural properties that may serve RYMV functions to infect and invade the host plant.

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Iminodiacetic Acid Derivatives

Cited by 4 publications

References 264 publications

Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches

Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches

Method To Determine MgO and MgOHCl in Chloride Molten Salts

An original structural fold underlies the multitask P1, a silencing suppressor encoded by the Rice yellow mottle virus

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