Abstract:Q203 (telacebec)
is an imidazopyridine amide (IPA) targeting the
respiratory CIII2CIV2 supercomplex of the mycobacterial
electron transport chain (ETC). Aiming for a better understanding
of the molecular mechanism of action of IPA, 27 analogues were prepared
through a seven-step synthetic scheme. Oxygen consumption assay was
designed to test the inhibition of purified Mycobacterium
smegmatis CIII2CIV2 by these
compounds. The assay results generally supported structure–activity
relationship information obtained… Show more
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