Imidazolium chloride as an additive for synthesis of 4(3H)-quinazolinones using anthranilamides and DMF derivatives

A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants

“…Heterocycles containing the CR fragment have been synthetized from a variety of amino substrates (Scheme 24) [76][77][78][79]. Under the experimental conditions of Scheme 24a, activation of the carbonyl group of DMF by HMDS favors the nucleophilic addition of the arylamine leading to an intermediate that undergoes internal addition of the other nucleophilic moiety of the substrate.…”