Imidazolium‐Based Main‐Chain Copolymers With Alternating Sequences for Broad‐Spectrum Bactericidal Activity and Eradication of Bacterial Biofilms
Changjiang Liu,
Jialei Han,
Zeyuan Li
et al.
Abstract:In response to the escalating challenge of bacterial drug resistance, the imperative to counteract planktonic cell proliferation and eliminate entrenched biofilms underscores the necessity for cationic polymeric antibacterials. However, limited efficacy and cytotoxicity challenge their practical use. Here, we introduce novel imidazolium‐based main‐chain copolymers, with imidazolium (PIm+) as the cationic component. By adjusting precursor molecules, we fine‐tune hydrophobicity and cationic density of each unit,… Show more
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