Imidazoline use in sinonasal surgery

Estimation of biocidal activity of some imidazoline derivatives by using pathogenic bacterial and yeast strains

“…Then the sodium salts corresponding to the 2-imidazoline derivatives resulting by treating with sodium hydride in anhydrous THF were reacted with 2-chloro-methyl-imidazoline at room temperature leading to N-aryl-2-imidazolines. 15,17 The newly obtained derivatives were synthesized as described in literature, [18][19][20][21][22][23] by the condensation of the R 1 R 2 substituted sulfonamides of the methylic esters of the phenoxyacetic acids with ethylenediamine under acid catalysis (p-toluenesulfonic acid p-TsOH), followed by coupling the resulting derivatives with 2-chloromethylimidazoline in the presence of sodium hydride in anhydrous THF at room temperature as illustrated in the following reaction Figure 1.…”

“…The resulting N-alkylated products were separated by water addition followed by extraction in dichloromethane. [18][19][20][21][22][23]…”