Imidazoline receptors agonists: possible mechanisms of endothelioprotection

Солдатов, Владислав О.; Shmykova, Elena A.; Першина, М. А.; Ksenofontov, Andrey O.; Zamitsky, Yaroslav M.; Kulikov, Alexandr L.; Peresypkina, Anna A.; Dovgan, A. P.; Belousova, Yuliya V

doi:10.3897/rrpharmacology.4.27221

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Table 4 summarizes the most relevant results obtained in pharmacological studies related to the antihyperglycemic effect of TT. Alkaloids could act synergistically with the steroidal saponins, as it was shown that imidazolidine derivatives stimulate insulin secretion by activation of imidazoline receptor type 3 binding sites in the pancreatic beta cells [103].…”

Section: Preclinical Studiesmentioning

confidence: 99%

A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.

et al. 2020

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The general spread of Tribulus terrestris L. (South Africa, Australia, Europe, and India), the high content of active ingredients (in particular sterol saponins, as well as flavonoids, tannins, terpenoids, phenol carboxylic acids, and alkaloids), and its frequent uses in folk medicine, and as food supplements highlight the importance of evaluating its phytopharmacological properties. There are miscellaneous hypotheses that the species could have a high potential for the prevention and improvement of various human conditions such as infertility, low sexual desire, diabetes, and inflammatory diseases. Worldwide, numerous herbal supplements are commercialized with indications mostly to improve libido, sexual performance in both sexes, and athletic performance. Phytochemical studies have shown great disparities in the content of active substances (in particular the concentration of furostanol and spirostanol saponoside, considered to be the predominant active ingredients related to the therapeutic action). Thus, studies of experimental pharmacology (in vitro studies and animal models in vivo) and clinical pharmacology (efficacy and safety clinical trials) have sometimes led to divergent results; moreover, the presumed pharmacodynamic mechanisms have yet to be confirmed by molecular biology studies. Given the differences observed in the composition, the plant organ used to obtain the extract, the need for selective extraction methods which are targeted at the class of phytocompounds, and the standardization of T. terrestris extracts is an absolute necessity. This review aims to highlight the phytochemical, pharmacological, and toxicological properties of T. terrestris, with a focus on the contradictory results obtained by the studies conducted worldwide.

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Section: Preclinical Studiesmentioning

confidence: 99%

A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.

et al. 2020

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“…M odern pharmacology has a wide arsenal of compounds with cytoprotective potential. [1,2] In accordance with the requirements of esthetic and cosmetic medicine, the development of dermatotropic agents with woundhealing activity is actively conducted. One of these tools is a gel based on bischofite, a natural mineral with significant reserves in the territory of the Lower Volga region.…”

Section: Introductionmentioning

confidence: 99%

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Солдатов¹

2018

AJP

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Introduction: The currently available information on the bischofite mineral pharmacodynamics suggests that gels based on it have wound-healing properties. It was shown that bischofite has anti-inflammatory, immunomodulatory, and reparative activity. Materials and Methods: Experiments were performed on 36 male rats. Using a blade, a linear wound length of 50 mm was modeled. Animals were divided into four groups: (1) Control; (2) Bischofite (500 mg of gel with bischofite per wound area for 7 days); (3) Actovegin (500 mg of Actovegin gel on the wound area for 7 days); and (4) Contractubex (500 mg of Contractubex gel for 7 days wound area). About the wound healing effect of the drugs was judged by studying the physicomechanical properties, determining the concentration of hydroxyproline (HP), and calculating the ratio of collagen 1 and 3 types. Results: The greatest strength of the wound defect, significantly greater than in the control (P < 0.01), was obtained in the group that received the bischofite gel (13.70 ± 0.76 N). Actovegin also demonstrated a positive reparative effect (12.60 ± 0.63 N, P < 0.05), significantly lower (P < 0.01) than in the control strength was obtained in the group using Contractubex (9.65 ± 0.59 N). In the calorimetric analysis, it was found that the highest concentration of HP was contained in the tissues of wound defects in animals treated with Contractubex; however, there was no statistically significant difference with the control group, significantly lower in comparison with the control (P < 0.05) concentration of selenium, contained tissues of simulated wounds in animals treated with bischofite gel (79.7% of the control). When assessing the ratio of collagens I and III in the tissues of the wound defect when dyeing with picrosirius red, it was found that, by the number of mature collagen fibers, the studied groups can be arranged in the following sequence (descending): Bischofite > Actovegin > Control > Contractubex. Conclusions: The study showed that the best results were obtained with external use of the gel with bischofite. Actovegin has a less significant but pronounced reparative effect on this model. The least satisfactory results were obtained when applying Contractubex.

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“…Поиск новых лекарственных препаратов для лечения и профилактики заболеваний является актуальной задачей современной фармакологии [5,6,19]. Одним из таких направлений является создание лекарственных препаратов для лечения и профилактики преэклампсии [1,4].…”

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Correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B

Владимирович¹,

Викторович²,

Владимирович³

et al. 2020

Kursk Scientific and Practical Bulletin “Man and His Health”

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Objective. The aim of the study is to investigate the correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B. Materials and methods. The study was performed in 120 white female Wistar rats weighing 250-300 g. ADMA-like preeclampsia was used as experimental preeclampsia. To assess the effectiveness of the pharmacological agents used, blood pressure, microcirculation in the placenta, and proteinuria were recorded, the content of final NO metabolites in the blood plasma was determined, and the coefficient of endothelial dysfunction was calculated. 50 μg / kg polypeptides (P-αB3 and P-αB4) were used as pharmacological agents, obtained by attaching to the original 11-amino acid peptide PHBSP [PubChem CID: 91810664], which is the amino acid chain Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (QEQLERALNSS) of KGD group from different ends of the chain. Results. The use of the studied derivatives of peptide imitating erythropoietin α-helix B with ADMA-like preeclampsia leads to a pronounced correction of disorders. The greatest effect was observed with the introduction of the peptide with the laboratory code P-αB4. A significant decrease in systolic and diastolic pressure was noted, respectively, improved microcirculation in the placenta, restoration of the NO-synthesizing function of the endothelium, and a decrease in proteinuria. Conclusion. The results obtained indicate the prospect of further research on the effectiveness of short-chain derivatives of erythropoietin imitating its α-helix B for the correction of functional disorders in preeclampsia.

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Imidazoline receptors agonists: possible mechanisms of endothelioprotection

Cited by 4 publications

References 31 publications

A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.

A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.

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Correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B

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