Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Molinaro, Antonio; Lassen, Pierre Bel; Henricsson, Marcus; Wu, Hao; Adriouch, Solia; Belda, Eugeni; Chakaroun, Rima; Nielsen, Trine; Bergh, Per-Olof; Rouault, Christine; Marquet, Florian; André, Sébastien; Salem, Joe‐Elie; Assmann, Karen E.; Bastard, Jean‐Philippe; Forslund, Kristoffer; Falony, Gwen; Pons, Nicolas; Prifti, Edi; Quinquis, Benoît; Roume, Hugo; Vieira-Silva, Sara; Hansen, Tue H.; Pedersen, Helle; Lewinter, Christian; Søndertoft, Nadja B; Køber, Lars; Vestergaard, Henrik; Hansen, Torben; Zucker, Jean-Daniel; Galán, Pilar; Dumas, Marc; Raes, Jeroen; Oppert, Jean‐Michel; Letunić, Ivica; Nielsen, Jens; Bork, Peer; Ehrlich, S. Dusko; Stümvoll, Michael; Pedersen, Oluf; Aron‐Wisnewsky, Judith; Clément, Karine; Bäckhed, Fredrik

doi:10.1038/s41467-020-19589-w

Cited by 127 publications

(113 citation statements)

References 61 publications

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“…This is consistent with previous work showing that histidine supplementation results in an improvement in insulin sensitivity and lower body fat [55]. Several bacterial metabolites derived from histidine were also increased in SubB-colonized mice in the inulin diet compared to SubA-colonized animals, including imidazole propionate (Table S6), which has been linked to impaired insulin signaling and type II diabetes in humans [15,56].…”

Section: Amino Acids and Lipid Metabolic Pathways Associate With Host Phenotypessupporting

confidence: 91%

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

et al. 2021

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Background There is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and by increasing production of beneficial metabolites in the distal gut. However, human studies have reported variations in the observed benefits among individuals consuming the same fiber. Several factors likely contribute to this variation, including host genetic and gut microbial differences. We hypothesized that gut microbial metabolism of dietary fiber represents an important and differential factor that modulates how dietary fiber impacts the host. Results We examined genetically identical gnotobiotic mice harboring two distinct complex gut microbial communities and exposed to four isocaloric diets, each containing different fibers: (i) cellulose, (ii) inulin, (iii) pectin, (iv) a mix of 5 fermentable fibers (assorted fiber). Gut microbiome analysis showed that each transplanted community preserved a core of common taxa across diets that differentiated it from the other community, but there were variations in richness and bacterial taxa abundance within each community among the different diet treatments. Host epigenetic, transcriptional, and metabolomic analyses revealed diet-directed differences between animals colonized with the two communities, including variation in amino acids and lipid pathways that were associated with divergent health outcomes. Conclusion This study demonstrates that interindividual variation in the gut microbiome is causally linked to differential effects of dietary fiber on host metabolic phenotypes and suggests that a one-fits-all fiber supplementation approach to promote health is unlikely to elicit consistent effects across individuals. Overall, the presented results underscore the importance of microbe-diet interactions on host metabolism and suggest that gut microbes modulate dietary fiber efficacy.

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Section: Amino Acids and Lipid Metabolic Pathways Associate With Host Phenotypessupporting

confidence: 91%

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

et al. 2021

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“…Thus, this study confirms that in type 2 diabetes, the intestinal microbiota may is switched towards IMP production, which can impact host inflammation and metabolism. 95 …”

Section: Disrupted Equilibrium Of the Gut Microbiome-host Interactions In Metabolic Disordersmentioning

confidence: 99%

Gut microbiota-derived metabolites as central regulators in metabolic disorders

Agus

Clément

Sokol

2020

Gut

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Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact with the host by the production of a diverse reservoir of metabolites, from exogenous dietary substrates or endogenous host compounds. Metabolic disorders are associated with alterations in the composition and function of the gut microbiota. Specific classes of microbiota-derived metabolites, notably bile acids, short-chain fatty acids, branched-chain amino acids, trimethylamine N-oxide, tryptophan and indole derivatives, have been implicated in the pathogenesis of metabolic disorders. This review aims to define the key classes of microbiota-derived metabolites that are altered in metabolic diseases and their role in pathogenesis. They represent potential biomarkers for early diagnosis and prognosis as well as promising targets for the development of novel therapeutic tools for metabolic disorders.

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“…Another study found that in mice, α-MSH was upregulated after nutrient-induced E. coli growth and led to increased plasma PYY and GLP-1 release and activated POMC neurons [ 131 ]. Finally, imidazole propionate (ImP, derived from gut-microbiota-processed dietary histidine) results in insulin resistance and subsequent type 2 diabetes [ 132 , 133 ]. Moreover, recent data showed that ImP is present in the forebrains of mice, thus underscoring that it can pass the BBB and therefore affect neurodevelopmental trajectories, including the gut–brain axis [ 134 , 135 ].…”

Section: Gut Microbiota and Metabolites And Feeding Behaviormentioning

confidence: 99%

The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications

Son

Koekkoek

Fleur

et al. 2021

IJMS

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Interaction between the gut and the brain is essential for energy homeostasis. In obesity, this homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a global epidemic that affects individual health and strains the socioeconomic system. Microbial dysbiosis has long been reported in obesity and obesity-related disorders. More recent literature has focused on the interaction of the gut microbiota and its metabolites on human brain and behavior. Developing strategies that target the gut microbiota could be a future approach for the treatment of obesity. Here, we review the microbiota–gut–brain axis and possible therapeutic options.

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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Cited by 127 publications

References 61 publications

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

Gut microbiota-derived metabolites as central regulators in metabolic disorders

The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications

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