Imidazole-Containing Peptidomimetic NACA as a Potent Drug for the Medicinal Treatment of Age-Related Cataract in Humans

Babizhayev, Mark A.; Yermakova, Valentina N.; Deyev, Anatoly I.; Seguin, Marie-Christine

doi:10.1089/rej.1.2000.3.43

Cited by 28 publications

(54 citation statements)

References 11 publications

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“…The subjects ranged in age from 55 to 72 years (mean B SD, 62 B 5 years); 51% were female, with 100% being white. Subjects who were cataract free had to meet the same inclusion criteria as the subjects with cataract described previously [13,16], except that they were required to be free of cataract and to have a best-corrected visual acuity of 20/25 in each eye, according to medical record review. No cataract-free subjects had secondary eye conditions other than refractive error.…”

Section: Methodsmentioning

confidence: 99%

“…For each eye, visual acuity measurements were grouped into 4 categories: 20/25 or better, 20/25-20/30, 20/35-20/50 and worse than 20/50. Disability glare was defined with an optical instrument and method for measuring susceptibility to glare of a human vision system as described [13,[16][17][18] and schematically presented in the diagram ( fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…By assessing the visual functions of a driver during driving in a real traffic situation under various circumstances of weather and illumination (daytime, dusk, nighttime, city traffic, country road), the limits of adaptation to luminance, object size, object contrast and color can be quantitatively determined. For the glare situation, typical values of glare angle and corneal illuminance of the glare light and the induced reduction of contrast can be determined with a potent glare disability test [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Since fitness for night driving, self-defence ability and good orientation under difficult visual conditions are mandatory for police officers, any ophthalmological certificate should make definite statements about glare and contrast sensitivity. The purpose of this article was to examine the type of visual impairment mediated by the increased glare sensitivity in adult drivers using the previously described and patented halometer glare test [13,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Glare Disability and Driving Safety

Babizhayev

2003

Ophthalmic Res

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Purpose: Increasing investigation of the visual elements of safe driving environments may be of great benefit to society. Visual disability appears to be only one of many visual factors related to traffic accidents. The purpose of this article was to examine the type of visual impairment mediated by the increased glare sensitivity in adult drivers using the original halometer glare test. Methods: In this article, the visual sensory, cognitive and motor functions relevant to driving, their measurement, the epidemiology and prevention of age-associated functional impairments and the relationship of functional impairments to both self-reported driving and the imposition of legal restrictions are reviewed. Results: The problem of night and tunnel driving is the most urgent in relation to the effects of glare from vehicle headlights on motion perception of drivers. The reduced mesopic vision and increased sensitivity to glare are accompanied by an increased risk of nighttime accidents. Elderly drivers and patients with beginning cataract cannot sufficiently fulfill the criteria for night driving ability because of contrast and glare sensitivity. It is indispensable for the parameters mentioned to be carefully measured and for drivers to be informed that night driving ability may be impaired, even if visual acuity is sufficient. Conclusions: It would be advisable for traffic safety if simple tests for contrast and glare sensitivity were implemented for vehicles and/or were regularly added to the requirements for a driver’s licence, at least for older drivers. The age, functional status and test result limits should be defined to avoid a risk factor in traffic.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glare Disability and Driving Safety

Babizhayev

2003

Ophthalmic Res

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“…It can oppose glycation [140,141] and it can chelate divalent metal ions [142]. The important studies have produced clinical and experimental evidence of beneficial effects of N-acetylcarnosine in treating cataracts of the eyes; these and other ophthalmological benefits have been proven [14,15,[143][144][145][146][147][148][149][150][151]. Carcinine (β-alanyl histamine) is an imidazole dipeptide first discovered in the crustacean Carcinus maenas (reviewed in refs.…”

Section: Telomere Shortening Telomerase Enhancers and Immune Systemmentioning

confidence: 99%

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

Babizhayev¹,

Vishnyakova

Yegorov

2014

Journal of Basic and Clinical Physiology and Pharmacology

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It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, and telomere length (TL) may be an informative biomarker of healthy aging. Hormone-brain-aging behaviormodulated telomere dynamics and changes in telomerase activity are consistent elements of cellular alterations associated with changes in proliferative state, and these processes are consequently considered as the new therapeutic drug targets for physiological control with advanced drug delivery and nutritional formulations. We raise and support a therapeutic concept of using nonhydrolyzed forms of naturally occurring neuron-specific imidazole dipeptide-based compounds carnosine and carcinine, making it clinically possible that slowing down the rate of telomere shortening could slow down the human aging process in specific tissues where proliferative senescence is known to occur, with the demonstrated evidence of telomere shortening that appeared to be a hallmark of oxidative stress and disease. Carnosine released from skeletal muscle during exercise may be transported into the hypothalamic tuberomammillary nucleus (TMN) histamine neurons and hydrolyzed. The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and hormone-like antiaging physiological function. The preliminary longitudinal studies of elderly individuals suggest that longer telomeres are associated with better survival, and an advanced oral nutritional support with nonhydrolyzed carnosine (or carcinine and patented compositions thereof) is a useful therapeutic tool for a critical TL maintenance that may fundamentally be applied in the treatment of age-related sight-threatening eye disorders, prolonged life expectancy, increased survival and chronological age of an organism in health control, smoking behavior, and disease."Our pleasures were simple-they included survival." -Dwight D. Eisenhower, 34th President of the United States, 1953States, -1961

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