Imidazole Alkaloids from Lepidium meyenii

Cui, Bo; Zheng, Bo; He, Kan; Zheng, Qun Yi

doi:10.1021/np030031i

Cited by 208 publications

(165 citation statements)

References 7 publications

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“…Maca has recently been studied profusely because of the diverse pharmacological properties, such as fertility enhancer, sexual performance effects, and endurance capacity enhancer (Cicero et al 2001;BustosObregón et al 2005;Ruiz-Luna et al 2005). The maca root contains high nutritional value component (Dini et al, 1994) and several unique secondary metabolites, such as macamides, macaene, alkaloids, glucosinolates, and sterols (Ganzera et al 2002;Muhammad et al 2002;Piacente et al 2002;Cui et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Yang

Jin

et al. 2015

Pharmaceutical Biology

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Objective: The present study investigates the effects of macamides on endurance capacity and antifatigue property in prolonged swimming mice. Materials and methods: The Balb/c mice were divided into seven groups: a control group, low-dose groups of N-benzyllinoleamide, N-benzyloleamide, and N-benzylpalmitamide, high-dose groups of these macamides. The macamides groups received the commercial products (12 and 40 mg/kg, ig), while the control group received vehicle for 21 d. On the 14th day, the mice were given the weightloaded swimming test. On the 21st day, the mice were sacrificed immediately after 90 min swimming, and some biochemical parameters were measured. Results and discussion: Compared with the control group, exhaustive swimming time was significantly prolonged in high-dose group of N-benzyloleamide (p50.05); the levels of lactic acid (LD), blood ammonia (BA), and lactate dehydrogenase (LDH) were significantly decreased (p50.05), whereas the levels of liver glycogen (LG) and non-esterified fatty acid (NEFA) were significantly increased (p50.05) in high-dose group of N-benzyloleamide. The malondialdehyde (MDA) contents in the brain, muscle, and liver were significantly decreased (p50.05), whereas superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the brain, muscle, and liver were significantly increased in high-dose group of N-benzyloleamide (p50.05). Conclusion:The results indicate that N-benzyloleamide has pharmaceutical property against exercise-induced fatigue, and this effect can be explained by the modulated energy metabolism and improved antioxidant status.

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Section: Introductionmentioning

confidence: 99%

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Yang

Jin

et al. 2015

Pharmaceutical Biology

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“…All the results are list in scheme 5 and table 3. 18 , which exhibit micromolar cytotoxicity against several human cancer cell lines, were isolated from the root extract of lepidium meyenii collected from the Andes Mountains of Peru during a search for bioactive natural products. We synthesized Lepidiline B using our method described above.…”

Section: Scheme 4 Synthesis Of Trisubsituted Imidazolesmentioning

confidence: 99%

One-Pot Synthesis of Polysubstituted Imidazoles From Arylaldehydes in Water Catalyzed by NHC Using Microwave Irradiation

Jing

Zhu

et al. 2012

J. Chil. Chem. Soc.

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A simple, high yielding synthesis of tri (3a-i) and tetrasubstituted (4a-g) imidazols from aldehydes is described. The cornerstone of this methodology involves the condensation of NH 4 OAc, substituted aldehydes, and benzoin, which is synthesized in situ from aldehydes catalyzed by N-heterocyclic carbine (NHC), under microwave irradiation in water to afford trisubstituted imidazoles (3a-i). If arylamine is added in the solution, tetrasubstituted imidazoles (4a-g) can be obtained. Lepidilines B and trifenagrel are also synthesized in high yield using this procedure. All the experiment deta are in agreement with the literature.

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“…), a biennial herbaceous plant of the family brassicae, which is cultivated mainly in the central Andes of Peru at elevations of 3500-4500 m above sea level, has been used as both a food and a traditional medicine in the region for over 2000 years [1]. Domestic and foreign experts researched on the nutritional compositions and secondary metabolites of maca, finding that it not only contains rich protein, amino acids, fat, and minerals ion [2] but also contains a variety of secondary metabolites: maca ene, alkaloid (including maca amide), glucosinolate, and other components [3][4][5]. These secondary metabolites are considered closely related to the health effects of maca.…”

Section: Introductionmentioning

confidence: 99%

The Composition Analysis of Maca (Lepidium meyeniiWalp.) from Xinjiang and Its Antifatigue Activity

Chen

Duan

et al. 2017

Journal of Food Quality

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Environment would affect the nutritional composition of maca, especially its secondary metabolite. The chemical compositions and function of Xinjiang maca were not very clear. The chemical compositions and bioactivity of Xinjiang maca were determined. A mouse model was also used to evaluate the antifatigue activity of Xinjiang maca as a forced swimming test was performed and certain biochemical parameters related were estimated. The results show that the Xinjiang maca is rich in protein content and amino acids, especially branched chain amino acids such as Valine and Isoleucine related to the effect of antifatigue. It also has considerable minerals ions such as Ca and Mg. Besides, bioactive ingredients such as maca amide, glucosinolate, and alkaloid of Xinjiang maca are similar to those of maca from other areas, which qualify the biological value of Xinjiang maca. The results of mice model suggest that maca has a dose-dependent antifatigue activity by decreasing blood lactic acid, as well as increasing liver glycogen content and the forced swimming time.

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Imidazole Alkaloids from Lepidium meyenii

Cited by 208 publications

References 7 publications

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

One-Pot Synthesis of Polysubstituted Imidazoles From Arylaldehydes in Water Catalyzed by NHC Using Microwave Irradiation

The Composition Analysis of Maca (Lepidium meyeniiWalp.) from Xinjiang and Its Antifatigue Activity

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