Imidazo[1,2-a]pyridine-based hybrids. Copper-catalyzed cycloaddition synthesis, photophysics, docking, and interaction studies with biomacromolecules

Imidazopyridine Family: Versatile and Promising Heterocyclic Skeletons for Different Applications

“…Many of the developed synthetic approaches encountered certain limitations, often associated with the use of various catalysts such as Se(IV) [ 38 , 220 , 221 ], Pd(II) [ 222 , 223 ], Fe(II) and Fe(III) [ 224 , 225 ], Cu(II) ion [ 226 , 227 , 228 , 229 ], CuCl 2 [ 230 , 231 , 232 ], copper/iodine [ 233 ], Cu-MOF structures [ 234 , 235 ], boron trifluoride etherate [ 236 ], CBr 4 [ 237 ] or MnO 2 [ 53 ]. In addition, some catalysts require further reagents or co-catalysts such as selenium dioxide [ 238 ], dehydrating agents (e.g., molecular sieves [ 239 ] or propane phosphoric acid anhydride [ 213 ]), Lewis acids (BF 3 ), or oxidant agents (e.g., oxygen, iodine [ 240 , 241 ], elemental sulfur [ 242 ], or tert -butylperoxybenzoate) [ 243 ].…”

Photoactive glycoconjugates with a very large Stokes shift: synthesis, photophysics, and copper(ii) and BSA sensing

“…(3aR,4R,6R,6aR)-4-Methoxy-2,2-dimethyl-6((2-propene-1-yloxy) methyl)tetrahydrofuro [3,4-d][1,3]dioxol (8). Yield: 82% (0.563 g).…”

“…Carbohydrates have natural availability, polyfunctionality, and low toxicity, making them ideal candidates for designing functional molecules with coordination sites for metals. 6,7,8 Therefore, glycoconjugation represents a promising strategy for synthesizing fluorescent sensors that can play a crucial role in analytical applications, offering a valuable tool for detecting and quantifying various analytes of interest. 9 The development of a chemosensor requires a carefully planned molecule with two essential components: a receptor site for analyte binding and a signaling unit, typically a fluorophore or chromophore.…”

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

“…Specifically, imidazo[1,2‐a]pyridine derivatives, a subclass of imidazopyridines, are of particular interest due to their promising therapeutic potential in various medical fields [8–10] . They exhibit diverse pharmacological activities, including anticancer, anti‐inflammatory, antiulcer, analgesic, antiprotozoal, antipyretic, antiviral, and other activities [11,12] . Moreover, imidazo[1,2‐a]pyridines have demonstrated efficacy in treating psychiatric disorders and autoimmune conditions, further expanding their medical applications [13,14] …”

“…[8][9][10] They exhibit diverse pharmacological activities, including anticancer, anti-inflammatory, antiulcer, analgesic, antiprotozoal, antipyretic, antiviral, and other activities. [11,12] Moreover, imidazo [1,2-a]pyridines have demonstrated efficacy in treating psychiatric disorders and autoimmune conditions, further expanding their medical applications. [13,14] The ability of imidazo [1,2-a]pyridines to interact with various targets, such as melatonin receptors, DNA alkylating agents, and activin-like kinase (ALK2), underscores their potential for developing new therapeutic agents.…”