The CHINAGUT Conference, a biennial event dedicated to gut science, has grown significantly since its inception in 2018. Its 4th iteration, CHINAGUT 2023, was held from May 19 to 22 at the Beijing National Convention Center, attracting over 10,000 attendees. This large-scale academic interchange, organized by numerous academic and industrial entities, has become China's premier conference on gut-related research. This year's conference showcased an evolved content structure with a comprehensive call for submissions, channeling over 60% of oral presentations from submitted abstracts. The conference was organized into 14 major academic tracks reflecting hot research fields