Imbalances in the neurotrophic effects of noradrenaline, favouring the positive in the child and the negative in the mother, are the cause of preeclampsia

The balance between the pro-inflammatory effect of plasma noradrenaline and the anti-inflammatory effect of neuronal noradrenaline determines the peripheral effects of noradrenaline

“…That same shift in favour of NNA stimulation and hypertrophy occurs in preeclampsia [48] where a factor that decreases perfusion of the uterus shifts the noradrenergic ratio of that organ in favour of the growth promoting effect of NNA and causes it to hypertrophy [49]. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 26 stimulation, or to release [ 3 H] labelled NA 51].…”

“…the shift is in favour of PNA; in her uterus and conceptus it is believed to be in favour of NNA [48]. Consistent with that dichotomy, one investigator has claimed preeclampsia has a heterogenous cause [123].…”

“…Consistent with that dichotomy, one investigator has claimed preeclampsia has a heterogenous cause [123]. The contrasting shifts in ratios in preeclampsia are believed to result from the pregnant uterus becoming retroflexed and compressing the aorta against the lordotic curve of the spine [122] or the brim of the pelvis [48] with the result, in both cases, of reducing blood flow 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 42 beyond the compression by a minimum 40-50 % [123] and causing ischaemia of the uterus and the conceptus which are supplied by arteries originating distal to the compression.…”