Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients

Abstract

Cold Syndrome and Hot Syndrome are thousand-year-old key therapeutic concepts in traditional Chinese medicine (TCM), which depict the loss of body homeostasis. However, the scientific basis of TCM Syndrome remains unclear due to limitations of current reductionist approaches. Here, we established a network balance model to evaluate the imbalanced network underlying TCM Syndrome and find potential biomarkers. By implementing this approach and investigating a group of chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG) patients, we found that with leptin as a biomarker, Cold Syndrome patients experience low levels of energy metabolism, while the CCL2/MCP1 biomarker indicated that immune regulation is intensified in Hot Syndrome patients. Such a metabolism-immune imbalanced network is consistent during the course from CSG to CAG. This work provides a new way to understand TCM Syndrome scientifically, which in turn benefits the personalized medicine in terms of the ancient medicine and complex biological systems.

Relationship of the Cold‐Heat Sensation of the Limbs and Abdomen with Physiological Biomarkers

“…The four main patterns are Yin-Yang, Cold-Heat, Deficiency-Excess, and Interior-Exterior [2]. Although there have been several attempts to explore the essence of PI using scientific principles [3–6], no consensus has been reached on whether PI is natural or an artifact and on what appropriate approach and surrogate biomarkers should be used for PI investigation [7]. …”

The Application of TCM Thought of Preventive Treatment of Disease in Clinical Practice

“…It is divided into two categories: chronic non-atrophic gastritis (superficial) and chronic atrophic gastritis (endogenous chronic gastritis) [8] . From the perspective of life and clinical observation, the occurrence of spleen and stomach diseases are mostly related to diet, emotional problems, eating disorders, emotional disorders lead to spleen and stomach dysfunction, spleen and stomach loss, liver and stomach discord, liver depression and spleen and other cards, so spleen and stomach Disease, the focus of disease prevention is not in the diet, flirting.…”

Traditional Chinese Medicine as Prevention and Treatment Strategies of HIV Infection

“…The attitude of TCM emphasizes regulating the integrity of a human body as well as the interaction between human individuals and their environment [64]. The theory of systematic biology helps human being to conceive the limitations of reductionism.…”