Imbalanced functional link between valuation networks in abstinent heroin-dependent subjects

Xie, Chunming; Shao, Yuanyuan; Ma, Liang-Xiao; Zhai, Tianye; E, Ye; Fu, Lei; Bi, Guo-Qiang; Chen, G; Cohen, Alexander D.; Li, Wei; Zheng, Yang; Sj, Li

doi:10.1038/mp.2012.169

Cited by 42 publications

(40 citation statements)

References 11 publications

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“…That processing in the nucleus accumbens core can indeed influence DA transmission in the aDLS was further demonstrated using in vivo voltammetry in rats self-administering cocaine in which late-developing, drug CS-evoked DA transients in the aDLS were completely prevented by a specific nucleus accumbens core (NAcbC) lesion (Willuhn et al 2012). Remarkably, functional coupling between the ventral and the dorsal striatum has also been shown in former heroin addicts, together with decreased functional coupling between the striatum and the PFC (Xie et al 2014). Neurocomputational models of addiction have successfully incorporated this concept (Dezfouli et al 2009, Piray et al 2010, which may be linked to earlier notions of a reinforcement learning model, which assigns the role of critic to the nucleus accumbens that modulates the actor role over action selection assigned to the dorsal striatum (O'Doherty et al 2004).…”

Section: Transition From Ventral To Dorsal Striatummentioning

confidence: 88%

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Everitt

Robbins

2016

Annu. Rev. Psychol.

949

773

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A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum. Here, in the light of burgeoning, supportive evidence, we reconsider and elaborate this hypothesis, in particular the refinements in our understanding of ventral and dorsal striatal mechanisms underlying goal-directed and habitual drug seeking, the influence of drug-associated Pavlovian-conditioned stimuli on drug seeking and relapse, and evidence for impairments in top-down prefrontal cortical inhibitory control over this behavior. We further review animal and human studies that have begun to define etiological factors and individual differences in the propensity to become addicted to drugs, leading to the description of addiction endophenotypes, especially for cocaine addiction. We consider the prospect of novel treatments for addiction that promote abstinence from and relapse to drug use.

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Section: Transition From Ventral To Dorsal Striatummentioning

confidence: 88%

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Everitt

Robbins

2016

Annu. Rev. Psychol.

949

773

View full text Add to dashboard Cite

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“…As a result, the weaker δ-network FC strength, coupled with stronger β-network FC strength, implicated the mutually reinforcing pattern to synergistically tilt the network balance toward motivational drive and lead to impulsive behaviors (i.e., δ i - β i value is negative). It has been suggested that this imbalanced neural mechanism may be the neural underpinning of aberrant behaviors in drug addiction (Volkow et al, 2013; Xie et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Nature of functional links in valuation networks differentiates impulsive behaviors between abstinent heroin-dependent subjects and nondrug-using subjects

Zhai

Shao²,

Chen

et al. 2015

NeuroImage

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Advanced neuroimaging studies have identified brain correlates of pathological impulsivity in a variety of neuropsychiatric disorders. However, whether and how these spatially separate and functionally integrated neural correlates collectively contribute to aberrant impulsive behaviors remains unclear. Building on recent progress in neuroeconomics towards determining a biological account of human behaviors, we employed resting-state functional MRI to characterize the nature of the links between these neural correlates and to investigate their impact on impulsivity. We demonstrated that through functional connectivity with the ventral medial prefrontal cortex, the δ-network (regions of the executive control system, such as the dorsolateral prefrontal cortex) and the β-network (regions of the reward system involved in the mesocorticolimbic pathway), jointly influence impulsivity measured by the Barratt Impulsiveness Scale scores. In control nondrug-using subjects, the functional link between the β- and δ-networks is balanced, and the δ-network competitively controls impulsivity. However, in abstinent heroin-dependent subjects, the link is imbalanced, with stronger β-network connectivity and weaker δ-network connectivity. The imbalanced link is associated with impulsivity, indicating that the β- and δ-networks may mutually reinforce each other in abstinent heroin-dependent subjects. These findings of an aberrant link between the β- and δ-networks in abstinent heroin-dependent subjects may shed light on the mechanism of aberrant behaviors of drug addiction and may serve as an endophenotype to mark individual subjects’ self-control capacity.

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“…At the neurobiological level, addicted rats are characterized by an impairment in synaptic plasticity in the ventral striatum [93] and its cortical afferent, the medial prefrontal cortex [66], suggesting that addiction, at least to cocaine, is associated with impaired fronto-striatal connectivity in rats, as it has been shown in alcoholics [96] or former heroin addicts [97]. These findings are also in agreement with a recent demonstration that altered synaptic plasticity in the prelimbic cortex supports compulsive drug-seeking behavior in rats trained in a seeking-taking task [26] (see below).…”

Section: Instrumental and Pavlovian Mechanisms Subserving Drug Use: Dmentioning

confidence: 99%

How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction

Belin

Fouyssac

Bonci

et al. 2016

Biological Psychiatry

109

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Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained despite adverse consequences and intense drug craving. Despite extensive research, the pathophysiology and aetiology of addiction is only partially understood, due to the gap between current preclinical models of addiction and the clinical criteria of the disorder. Here we give a brief overview, based on selected methodologies, of how behavioral models have evolved over the last fifty years to the development of recent preclinical models of addiction that more closely mimic diagnostic criteria of addiction. These new models will hopefully increase our understanding of the complex neurobiological mechanisms whereby some individuals switch from controlled drug use to compulsive drug-seeking habits and relapse to these maladaptive habits. Additional, by paving the way to bridge the gap that exists between biobehavioral research on addiction and the human situation, these models may provide new perspectives for the development of novel and effective therapeutic strategies for drug addiction.

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Imbalanced functional link between valuation networks in abstinent heroin-dependent subjects

Cited by 42 publications

References 11 publications

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Nature of functional links in valuation networks differentiates impulsive behaviors between abstinent heroin-dependent subjects and nondrug-using subjects

How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction

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