Imbalanced anti-H1N1 immunoglobulin subclasses and dysregulated cytokines in hospitalized pregnant women with 2009 H1N1 influenza and pneumonia in Shenyang, China

Zheng, Rui; Qin, Xiaosong; Li, Yang; Yu, Xiaojun; Wang, Jun; Tan, Mingqi; Zhou, Yang; Li, Wenjie

doi:10.1016/j.humimm.2012.06.005

Cited by 13 publications

(16 citation statements)

References 24 publications

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“…It remains uncertain whether administration of Igs to IgG2-deficient patients is likely to be therapeutically beneficial, although some studies report an IgG2-subclass deficiency in H1N1 infections during pregnancy. 93,94 Interestingly, convalescent blood products were administered during the 1918 Spanish influenza pandemic with a reduction in mortality. 208 A vaccination strategy providing broad protection against diverse influenza isolates could eliminate the need for annual vaccines and protect against emergent pandemic strains.…”

Section: Immunotherapymentioning

confidence: 99%

“…These findings were confirmed in another recently published study from China, where the pregnant H1N1-infected population was shown to have an imbalance of anti-H1N1 Ig subclasses (IgG 1 , IgG 2 , IgG 3 , and IgG 4 ) and dysregulated cytokines, when compared to nonpregnant as well as uninfected pregnant controls. 94 The anti-H1N1 IgG 2 constituent proportion was decreased and IgG 4 was increased in the pregnant H1N1 group. This was also associated with a reduction in CD4þ and CD8þ T-cell percentages and a low CD4þ-CD8þ ratio in the same population.…”

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confidence: 94%

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Influenza, Immune System, and Pregnancy

2014

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Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt to explain the increased morbidity and mortality seen in infection during pregnancy. We discuss elements of innate and adaptive immunity as well as placental cellular responses to infection. In addition, we delineate findings in animal models as well as human disease. Increased knowledge of maternal and fetal immunologic responses to influenza is needed. However, enhanced understanding of nonimmune, pregnancy-specific factors influencing direct interaction of the virus with host cells is also important for the development of more effective prevention and treatment options in the future.

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Section: Immunotherapymentioning

confidence: 99%

mentioning

confidence: 94%

Influenza, Immune System, and Pregnancy

2014

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“…It is known that the activation of the maternal immune system by an infection during pregnancy induces the release of inflammatory cytokines (Shobokshi and Shaarawy, 2002; Zheng et al, 2012), but how these cytokines enter the fetal circulation and alter fetal brain development remains unclear.…”

Section: What Is the Source Of The Cytokines That Induce Fetal Brain mentioning

confidence: 99%

Cytokines and the neurodevelopmental basis of mental illness

et al. 2013

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Epidemiological studies suggest that prenatal exposure to different types of viral or bacterial infections may be associated with similar outcomes; i.e., an increased risk of mental illness disorders in the offspring. Infections arising from various causes have similar debilitating effects in later life, suggesting that the exact pathogen may not be the critical factor in determining the neurological and cognitive outcome in the offspring. Instead, it is thought that response of the innate immune system, specifically the increased production of inflammatory cytokines, may be the critical mediator in altering fetal brain development pre-disposing the offspring to mental illness disorders later in life. Inflammatory cytokines are essential for normal brain development. Factors such as the site of cytokine production, a change in balance between anti- and pro- inflammatory cytokines, placental transfer of cytokines, the effects of cytokines on glial cells, and the effects of glucocorticoids are important when evaluating the impact of maternal infection on fetal brain development. Although it is clear that cytokines are altered in the fetal brain following maternal infection, further evidence is required to determine if cytokines are the critical factor that alters the trajectory of brain development, subsequently leading to postnatal behavioral and neurological abnormalities.

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“…Increased expression of pro-inflammatory cytokines IL-1α, IL-6, IL-12, TNF-α, G-CSF, RANTES, and MCP-1, increased immunosuppressive cytokines IL-10 and IFN-γ, and type I and III IFNs reduction together alter the cellular microenvironment of the maternal lung and promote severe immunopathology-alterations that are compounded as pregnancy advances (Gonzalez et al 2009;Chan et al 2010;Kraus et al 2010;Marcelin et al 2011;Forbes et al 2012;Kim et al 2012a;Zheng et al 2012;Vanders et al 2013). Pregnancy in the ferret model supports these findings, as increased inflammatory cytokines in the lungs lead to cytokine imbalance and elevated viral replication compared with nonpregnant, influenza virus-infected controls (Yoon et al 2018).…”

Section: Pregnancymentioning

confidence: 99%

Influenza in High-Risk Hosts—Lessons Learned from Animal Models

Honce

Wohlgemuth

Meliopoulos

et al. 2019

Cold Spring Harb Perspect Med

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Factoring significantly into the global burden of influenza disease are high-risk populations that suffer the bulk of infections. Classically, the very young, very old, and pregnant women have been identified as high-risk populations; however, recent research has uncovered several other conditions that contribute to severe infection. By using varied animal models, researchers have identified molecular mechanisms underpinning the increased likelihood for infection due to obesity and malnourishment, as well as insight into the role sex hormones play in antiviral immunity in males, in females, and across the life span. Additionally, novel comorbidity models have helped elucidate the role of chronic infectious and genetic diseases in influenza virus pathogenesis. Animal models play a vital role in understanding the contribution of host factors to influenza severity and immunity. An in-depth understanding of these host factors represents an important step in reducing the burden of influenza among the growing number of people living with one or more chronic medical conditions.

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Imbalanced anti-H1N1 immunoglobulin subclasses and dysregulated cytokines in hospitalized pregnant women with 2009 H1N1 influenza and pneumonia in Shenyang, China

Cited by 13 publications

References 24 publications

Influenza, Immune System, and Pregnancy

Influenza, Immune System, and Pregnancy

Cytokines and the neurodevelopmental basis of mental illness

Influenza in High-Risk Hosts—Lessons Learned from Animal Models

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