Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Children with Henoch-Schönlein Purpura

Wang, Y B; Shan, Ning-ning; Chen, O; Gao, Yan; Zou, Xiong; Wei, De-E; Wang, C X; Zhang, Y

doi:10.1177/147323001103900616

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…Our results demonstrate the absence of a significant difference in circulating levels of IL‐18 between subjects with HSP and healthy controls. Wang et al reported higher IL‐18 and IL‐18 binding protein (IL‐18BP) levels in subjects with HSP than in controls and did not observe any significant difference in IL‐18 levels between patients with active disease and those in remission. In our study we observed a significant decline in IL‐18 levels with remission.…”

Section: Discussionmentioning

confidence: 99%

Levels of Interleukin‐18 and Endothelin‐1 in Children with Henoch‐Schönlein Purpura: A Study from Northern India

Mahajan

Kapoor

Bisht

et al. 2013

Pediatric Dermatology

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Henoch-Schönlein purpura (HSP) is an acute systemic vasculitis with unknown etiology, although several studies have found HSP to be related to cytokines such as tumor necrosis factor α, interleukin (IL)-1, and adhesion molecules. In the present study we determined the levels of cytokines such as IL-18 and endothelin-1 (ET-1) in children with HSP. Subjects were divided into three groups (group 1, 20 subjects with HSP; group 2, 10 subjects belonging to group 1 during their follow-up 4 to 6 months later; and group 3, 16 controls who were healthy siblings of the subjects). IL-18 and ET-1 levels were determined using enzyme immunoassay and expressed as mean ± standard deviation. We observed higher IL-18 levels in children with HSP (767.6 ± 145.1 pg/mL) than in controls (614.6 ± 66.54 pg/mL, p > 0.05), but IL-18 levels were found to be significantly lower in subjects with HSP in remission (502.7 ± 60.81 pg/mL) than in those who were in an active phase (1,050 ± 244.5 pg/mL, p < 0.05, n = 10). ET-1 levels were found to be significantly higher in subjects with HSP (1.93 ± 0.19 pg/mL) than in controls (1.10 ± 0.13 pg/mL, p < 0.05), although no significant difference was observed in ET-1 levels between subjects in group 1 (1.88 ± 0.30 pg/mL) and group 2 (1.91 ± 0.120, p > 0.05, n = 10). A positive correlation was observed between IL-18 and ET-1 levels in subjects with HSP (correlation coefficient [r] = 0.5254, p < 0.01). These results suggest that levels of IL-18 and ET-1 are worth monitoring during the clinical course of the disease, but caution must be exercised in extrapolating data based on small study samples.

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Section: Discussionmentioning

confidence: 99%

Levels of Interleukin‐18 and Endothelin‐1 in Children with Henoch‐Schönlein Purpura: A Study from Northern India

Mahajan

Kapoor

Bisht

et al. 2013

Pediatric Dermatology

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“…Wang et al showed a significantly higher level of IL-18 and IL-18 binding protein (IL-18BP) in active IgAV. They also showed a higher level of IL-18 in the acute phase compared with remission [39]. The elevated concentration of IL-18, which affects Th17 maturation and Th2 differentiation, may cause the above-mentioned increased proportions of the Th17 and Th2 in IgAV patients.…”

Section: Discussionmentioning

confidence: 91%

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children

et al. 2019

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“…Furthermore, serum or plasma levels of IL-18 were significantly higher in patients with IgA vasculitis than in controls and the activity of IgA vasculitis is associated with the titer of IL-18 (Wang et al 2011;Mahajan et al 2013). The imbalance of IL-18 and IL-18 binding protein, which is endogenous antagonist of IL-18, may promote inflammation in IgA vasculitis (Wang et al 2011). The susceptibility to IgA vasculitis by specific IL-18 gene promoter polymorphisms was previously suggested (Torres et al 2010).…”

Section: Discussionmentioning

confidence: 92%

“…The skin biopsy finding of IgA vasculitis in the acute phase revealed the positivity of IL-1 immunohistochemical staining in the nucleated epidermal layer (Besbas et al 1997), and rs16944 genetic variant of IL-1β may be a genetic marker of severe renal manifestation of IgA vasculitis (Lopez-Mejias et al 2016). Furthermore, serum or plasma levels of IL-18 were significantly higher in patients with IgA vasculitis than in controls and the activity of IgA vasculitis is associated with the titer of IL-18 (Wang et al 2011;Mahajan et al 2013). The imbalance of IL-18 and IL-18 binding protein, which is endogenous antagonist of IL-18, may promote inflammation in IgA vasculitis (Wang et al 2011).…”

Section: Discussionmentioning

confidence: 96%

Immunoglobulin A Vasculitis in a Japanese Patient with Complete Familial Mediterranean Fever Carrying <i>MEFV</i> Exon 10 Mutation

Sasajima¹,

Fujita

Ejiri³

et al. 2021

Tohoku J. Exp. Med.

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Immunoglobulin A (IgA) vasculitis is a systemic small-vessel vasculitis involving the skin, kidney, joints, and gastrointestinal tract. Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by periodic fever, peritonitis, pleuritis, or arthritis. It is well known that FMF may coexist with vasculitis, especially small and medium vessel vasculitis. Here we present a Japanese male patient with FMF who later developed IgA vasculitis and a relapsing disease course. A 51-year-old Japanese male was referred because of upper abdominal pain, arthralgia, and bilateral purpura of the lower limbs. He fulfilled the criteria for IgA vasculitis, which was successfully treated by corticosteroid and immunosuppressive therapy. He had a medical history of periodic fever since the age of 10 years old. The Mediterranean fever (MEFV) gene analysis revealed that he was heterozygous for M694I and E148Q mutations. Colchicine therapy resolved his periodic febrile attacks. To our knowledge, coexistence of FMF with IgA vasculitis has not been reported in East Asia, including Japan. Our case suggests that MEFV gene exon 10 mutations could be related to the development of IgA vasculitis and affects its clinical course.

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Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Children with Henoch-Schönlein Purpura

Cited by 8 publications

References 36 publications

Levels of Interleukin‐18 and Endothelin‐1 in Children with Henoch‐Schönlein Purpura: A Study from Northern India

Levels of Interleukin‐18 and Endothelin‐1 in Children with Henoch‐Schönlein Purpura: A Study from Northern India

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children

Immunoglobulin A Vasculitis in a Japanese Patient with Complete Familial Mediterranean Fever Carrying <i>MEFV</i> Exon 10 Mutation

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