Imbalance of GutStreptococcus,Clostridium, andAkkermansiaDetermines the Natural Course of Atopic Dermatitis in Infant

Park, Yoon Mee; Lee, So Yeon; Kang, Mi Jin; Kim, Bong Soo; Lee, Min Jung; Jung, Sung Soo; Yoon, Ji sun; Cho, Hyun Ju; Lee, Eun; Yang, Song I; Seo, Ju Hee; Kim, Hyo Bin; Suh, Dong In; Shin, Youn Ho; Kim, Kyung Won; Ahn, Kangmo; Hong, Soo Jong

doi:10.4168/aair.2020.12.2.322

Cited by 65 publications

(51 citation statements)

References 46 publications

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“…Additionally, the persisting reduction of Streptococcus after the probiotic supplementation [44] can be considered a positive effect of the intervention, as Streptococcus is a potentially pathogenic microorganism that could be directly involved in atopy [45] especially considering that it resulted in a biomarker of CMA in the present study.…”

Section: Discussionmentioning

confidence: 90%

Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation

Mennini

Reddel

Chierico

et al. 2021

IJMS

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Food allergy (FA) and, in particular, IgE-mediated cow’s milk allergy is associated with compositional and functional changes of gut microbiota. In this study, we compared the gut microbiota of cow’s milk allergic (CMA) infants with that of cow’s milk sensitized (CMS) infants and Healthy controls. The effect of the intake of a mixture of Bifidobacterium longum subsp. longum BB536, Bifidobacterium breve M-16V and Bifidobacterium longum subsp. infantis M-63 on gut microbiota modulation of CMA infants and probiotic persistence was also investigated. Gut microbiota of CMA infants resulted to be characterized by a dysbiotic status with a prevalence of some bacteria as Haemophilus, Klebsiella, Prevotella, Actinobacillus and Streptococcus. Among the three strains administered, B.longum subsp. infantis colonized the gastrointestinal tract and persisted in the gut microbiota of infants with CMA for 60 days. This colonization was associated with perturbations of the gut microbiota, specifically with the increase of Akkermansia and Ruminococcus. Multi-strain probiotic formulations can be studied for their persistence in the intestine by monitoring specific bacterial probes persistence and exploiting microbiota profiling modulation before the evaluation of their therapeutic effects.

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Section: Discussionmentioning

confidence: 90%

Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation

Mennini

Reddel

Chierico

et al. 2021

IJMS

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“…Moreover, infants who had Clostridium had a greater risk of developing AD 27 . Low numbers of Clostridium were found in children with persistent AD and allergies, and Clostridium was negatively correlated with SCORAD score in infants 19,28 . The perioral lesion of Prevotella spp.…”

Section: Discussionmentioning

confidence: 99%

Diversity analysis of gut microbiota between healthy controls and those with atopic dermatitis in a Chinese population

Yan

Wang

et al. 2020

The Journal of Dermatology

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An increasing body of evidence suggests that gut microbiota is involved in atopic dermatitis (AD). We aimed to use high‐throughput sequencing to characterize the differences in the composition of the gut microbiota between healthy controls and patients with AD. Fecal samples from 93 volunteers were analyzed using 16S rRNA sequencing, including 44 patients with AD and 49 healthy control subjects, aged 6–22 years. Our data show that the operational taxonomic unit composition in patients with AD had greater component similarity than the healthy controls. Patients with AD had a lower alpha diversity than healthy control subjects. The relative abundance of Porphyromonadaceae, Blautia, Parabacteroides, Bacteroides ovatus, Bacteroides uniformis and Prevotella stercorea was significantly higher (P < 0.05) in patients with AD than healthy control subjects. Clostridium and P. stercorea were higher (P < 0.05) in healthy control subjects compared with patients with AD. The results of linear discriminant analysis effect size show that Bacteroidaceae and Porphyromonadaceae can act as possible biomarkers associated with diagnosis of AD. However, this needs further experimental verification. Taken together, these results demonstrate the changes in microbiota composition in AD compared with a healthy control group, opening the way to future diagnosis or intervention studies.

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“…25 According to a recent study, the proportion of A. muciniphila was higher in children with transient AD than in children with non-AD or persistent AD. 26 However, in our study, the proportion ofAkkermansia was higher in children with AD than in children without AD because we included only the persistent AD subtype. Therefore more researches is needed to clarify these relationships.…”

Section: Discussionmentioning

confidence: 79%

Gut microbiome characteristics in mothers and infants according to the presence of atopic dermatitis

Sung

Choi

Park

et al. 2021

Preprint

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Background: The role of the gut microbiome in the onset and development of atopic dermatitis (AD) has been postulated. Therefore, we investigated the gut microbial compositions in infants with and without AD, and compared it to the gut bacterial flora of their mothers. Methods: This was a prospective and cross-sectional study. Among 44 pairs of mothers and children, we selected infants who were born via full-term normal vaginal delivery and that had no history of antibiotic or probiotic use, and infection during the first three months of life. The 15 pairs, consisting of nine healthy infants and six AD infants, were included in this study. Fecal samples of mothers and infants were analyzed within 30 days of delivery and at 12 months of age. Microbes in the fecal samples of mothers and infants were subjected to analysis of 16S rRNA amplicon sequencing. Results: Abundance of specific taxonomic groups was notably different, but microbial diversity and phylogenetic distances were not significantly different in either maternal or infant groups according to the presence of infant AD. A total of 12 species were selected as differential species in infants with AD compared to healthy infants. Six species were significantly different in the mothers of infants with AD compared to the mothers of healthy infants. Akkermansia muciniphila was only detected in healthy infants and their mothers. Conclusions: These data indicated that the presence of Akkermansia muciniphila in mothers and children after vaginal delivery is associated with the onset and development of AD.

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Imbalance of GutStreptococcus,Clostridium, andAkkermansiaDetermines the Natural Course of Atopic Dermatitis in Infant

Cited by 65 publications

References 46 publications

Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation

Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation

Diversity analysis of gut microbiota between healthy controls and those with atopic dermatitis in a Chinese population

Gut microbiome characteristics in mothers and infants according to the presence of atopic dermatitis

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