Imbalance between Subpopulations of Regulatory T Cells in Patients with Acute Exacerbation of COPD

Xia, Yang; Bo, Hanliang; Zhong, Xin; Su, Wenyan; Liu, Wenting; Li, Yumei; Zhou, He; Bai, Jing

doi:10.1080/15412555.2017.1385055

Cited by 12 publications

(12 citation statements)

References 40 publications

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“…Our study increased the sample size, and the results showed that the proportion of Treg cells in AECOPD and patients with SCOPD was signi cantly higher than that of HCs. Previous researchers have proposed that the imbalance of Th17/Treg cells plays an important role in the occurrence and development of COPD [32]. Our study showed that the expression of Th17 cells and Treg cells increased in AECOPD, but the increase in Th17 cells was more signi cant.…”

Section: Discussionsupporting

confidence: 45%

Immunophenotype in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Xiong

Zhu

et al. 2021

Preprint

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Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and the immune inflammatory response is thought to play an important role in pathogenesis. However, the immunophenotype of patients with COPD is unknown. Herein, we evaluated the immunophenotype of patients with acute exacerbation of COPD (AECOPD).Methods: A cross-sectional study was conducted in West China Hospital from September 2018 to October 2019. The proportion of CD4+ T lymphocyte subtypes (Th1, Th2, Th17 and Treg) and the levels of serum cytokines in the peripheral blood of patients with AECOPD, stable COPD (SCOPD), and healthy controls (HCs) were evaluated.Results: A total of 34 HCs, 53 patients with SCOPD, and 75 patients with AECOPD were included. Compared with patients with SCOPD, Th1 cells, Th17 cells, Treg cell ratio, Th1/Th2 cell ratio, and the levels of C-reactive protein, interleukin (IL)-6, and IL-10 were significantly increased in patients with AECOPD (P < 0.001), while the proportion of Th2 cells was significantly reduced (P < 0.01). The proportion of Th17 cells was positively correlated with COPD Assessment Test score (r = 0.243, P = 0.006), modified Medical Research Council dyspnea score (r = 0.326, P < 0.0001), and Th1 cell ratio (r = 0.353, P < 0.0001), and negatively correlated with the forced vital capacity (r = -0.308，P = 0.014) and proportion of Th2 cells (r = -0.653, P < 0.0001).Conclusions: The immunophenotype of patients with AECOPD shows abnormal activation of Th1, Th17 and Treg cells. There is a correlation between the proportion of Th17 cells and the severity of COPD; therefore, this may represent a novel index for the evaluation of COPD severity.Trial registration: China Clinical Trials Registry, ChiCTR1800018452, registered 19 September 2018, https://www.chictr.org.cn/index.aspx.

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Section: Discussionsupporting

confidence: 45%

Immunophenotype in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Xiong

Zhu

et al. 2021

Preprint

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“…The role of regulatory T cells (Tregs) and their different subpopulations in pulmonary diseases, has been studied extensively. Imbalances in these subpopulations have been linked to changes in clinical outcomes in different pulmonary conditions, including chronic obstructive pulmonary disease (COPD), asthma, sarcoidosis, pulmonary fibrosis, and lung cancer [1–3]. Changes in the local inflammatory milieu may add to altered Treg concentration and/or function in the airways.…”

Section: Introductionmentioning

confidence: 99%

Regulatory T Cells in Respiratory Health and Diseases

et al. 2019

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Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact have been widely studied in different clinical conditions including autoimmune diseases, inflammatory conditions, and cancer, amongst others. Tregs express transcription factor forkhead box P3 (FOXP3), which allows regulation of the immune response through anti-inflammatory cytokines such as IL-10 or transforming growth factor beta (TGF-β) and direct cell-to-cell interaction. Maintenance of immune tolerance is achieved via modulation of effector CD4+ T helper 1, 2 or 17 (Th1, Th2, Th17) cells by Tregs. This review highlights the recent progress in the understanding of Tregs in different disorders of the respiratory system.

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“…In COPD, TGF-β contributes to airway remodeling through a variety of mechanisms, including induction of Treg cells and associated foxp3 mRNA expression ( Zheng et al., 2018 ) ( Yang et al., 2017 ) ( Xu et al., 2019b ) ( Chu et al., 2016 ). However, obesity reduces circulating and lung resident FOXP3+ Treg cells, amplifying airway inflammation ( Ramos-Ramírez et al., 2020 ).…”

Section: Tgf-β1 and Copdmentioning

confidence: 99%

TGF-β: The missing link in obesity-associated airway diseases?

Woo

Koziol‐White

Panettieri

et al. 2021

Current Research in Pharmacology and Drug Discovery

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Obesity is emerging as a global public health epidemic. The co-morbidities associated with obesity significantly contribute to reduced quality of life, mortality, and global healthcare burden. Compared to other asthma comorbidities, obesity prominently engenders susceptibility to inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), contributes to greater disease severity and evokes insensitivity to current therapies. Unlike in other metabolic diseases associated with obesity, the mechanistic link between obesity and airway diseases is only poorly defined. Transforming growth factor-β (TGF-β) is a pleiotropic inflammatory cytokine belonging to a family of growth factors with pivotal roles in asthma. In this review, we summarize the role of TGF-β in major obesity-associated co-morbidities to shed light on mechanisms of the diseases. Literature evidence shows that TGF-β mechanistically links many co-morbidities with obesity through its profibrotic, remodeling, and proinflammatory functions. We posit that TGF-β plays a similar mechanistic role in obesity-associated inflammatory airway diseases such as asthma and COPD. Concerning the role of TGF-β on metabolic effects of obesity, we posit that TGF-β has a similar mechanistic role in obesity-associated inflammatory airway diseases in interplay with different comorbidities such as hypertension, metabolic diseases like type 2 diabetes, and cardiomyopathies. Future studies in TGF-β-dependent mechanisms in obesity-associated inflammatory airway diseases will advance our understanding of obesity-induced asthma and help find novel therapeutic targets for prevention and treatment.

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Imbalance between Subpopulations of Regulatory T Cells in Patients with Acute Exacerbation of COPD

Cited by 12 publications

References 40 publications

Immunophenotype in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Immunophenotype in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Regulatory T Cells in Respiratory Health and Diseases

TGF-β: The missing link in obesity-associated airway diseases?

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