Imbalance between production and scavenging of hydroxyl radicals in patients maintained on hemodialysis

Shirai, Sayuri; Ominato, Masayuki; Shimazu, Takekazu; Toyama, Katuhide; Ogimoto, Goichi; Fujino, Tomoya; Yasuda, Takashi; Sato, Takeo; Maeba, Teruhiko; Owada, Shigeru; Kimura, Kenjiro

doi:10.1007/s10157-005-0374-7

Cited by 7 publications

(12 citation statements)

References 19 publications

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“…The duration on HD therapy was found to correlate positively with levels of protein carbonyl group [6] and oxidized low-density lipoprotein [7] , but negatively with levels of protein sulfhydryl groups [6] and the antioxidants ␣ -tocopherol and ubiquinol [5] . These correlations should be ascribed to the increased levels of oxidative stress in HD patients.…”

Section: Discussionmentioning

confidence: 99%

“…These results indicate that in melanoma patients, both free 5SCD and pheomelanin are produced in melanoma cells and are secreted into the blood. On the other hand, it is assumed that in HD patients, pheomelanin is produced by oxidation of free 5SCD in the circulation because patients are exposed to high oxidative stress [5][6][7] . In support of this assumption, free 5SCD was shown to be oxidized by hydrogen peroxide-peroxidase, superoxide radicals, and hydroxyl radicals [19] .…”

Section: Discussionmentioning

confidence: 99%

“…Patients on long-term HD therapy suffer from increased levels of oxidative stress [5][6][7] . Although the precise mechanisms of oxidative stress have not been definitely elucidated, the interaction of blood with nonbiological materials of the extracorporeal circuit is considered to be one main source of extra-oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Serum Levels of Pigmentation Markers Are Elevated in Patients Undergoing Hemodialysis

Murakami¹,

Wakamatsu

Nakanishi

et al. 2007

Blood Purif

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Background: Diffuse hyperpigmentation is common among patients with chronic renal failure undergoing hemodialysis (HD). We have examined serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor), pheomelanin, eumelanin, and protein-bound (PB-) 3,4-dihydroxyphenylalanine (DOPA) and PB-5SCD in HD patients. Methods: Pheomelanin and eumelanin were assayed by chemical degradation methods. Results: Serum levels of free 5SCD in HD patients (n = 16) were 9-fold higher than in healthy controls (n = 16). Levels of pheomelanin in HD patients were 2.6-fold higher than in controls, while levels of eumelanin did not differ between HD patients and controls. Levels of PB-DOPA and PB-5SCD in HD patients were approximately 1.5-fold higher than in controls. Serum levels of free 5SCD were positively correlated to the duration of HD therapy. Conclusions: The high constitutive levels of free 5SCD, pheomelanin, and PB-DOPA in the blood may be deteriorating in HD patients through the production of reactive oxygen species.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum Levels of Pigmentation Markers Are Elevated in Patients Undergoing Hemodialysis

Murakami¹,

Wakamatsu

Nakanishi

et al. 2007

Blood Purif

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“…The lipid profile of CKD patients has been studied by several groups, but few have evaluated ox‐LDL levels . A study in HD patients that evaluated lipid peroxidation suggested that it is a main risk factor for CVD mortality .…”

Section: Introductionmentioning

confidence: 99%

“…The lipid profile of CKD patients has been studied by several groups, but few have evaluated ox-LDL levels. 8,9 A study in HD patients that evaluated lipid peroxidation suggested that it is a main risk factor for CVD mortality. 10 Adiponectin is an adipose-tissue cytokine that has been noted as an important antiatherogenic and antidiabetic protein and as an anti-inflammatory protein.…”

Section: Introductionmentioning

confidence: 99%

Oxidized low‐density lipoprotein and lipoprotein(a) levels in chronic kidney disease patients under hemodialysis: Influence of adiponectin and of a polymorphism in the apolipoprotein(a) gene

Ribeiro

Faria

Silva

et al. 2012

Hemodialysis International

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Chronic kidney disease (CKD) has been associated with an abnormal lipid profile. Our aim was to study the interplay between oxidized low-density lipoprotein (ox-LDL), adiponectin, and blood lipids and lipoproteins in Portuguese patients with CKD under hemodialysis (HD); the influence of the pentanucleotide repeat polymorphism in the apolipoprotein(a) (apo [a]) gene upon lipoprotein(a) (Lp[a]) levels in these patients. We studied 187 HD patients and 25 healthy individuals. ox-LDL and adiponectin were measured using enzyme-linked immunoassays. Apo(a) genotyping was performed by polymerase chain reaction, followed by electrophoresis in polyacrylamide gel. Compared with controls, patients presented with significantly higher levels of adiponectin, Lp(a), and ox-LDL/low-density lipoprotein cholesterol (LDLc) ratio; significantly lower levels of total cholesterol (TC), LDLc, apo A-I, apo B, ox-LDL, and TC/high-density lipoprotein cholesterol (HDLc) ratio were also observed. Similar changes were observed for patients with or without statin therapy, as compared with controls, except for Lp(a). Multiple linear regression analysis showed that body mass index, HDLc, time on HD, and triglycerides (TG) were independent determinants of adiponectin levels, and that apo B, TG and LDLc were independent determinants of ox-LDL concentration. Concerning the apo(a) genotype, the homozygous (TTTTA)8/8 repeats was the most prevalent (50.8%). A raised proportion of LDL particles that are oxidized was observed. Adiponectin almost doubled its values in patients and seems to be an important determinant in HDLc and TG levels, improving the lipid profile in these patients. Apo(a) alleles with a lower number of repetitions are more frequent in patients with higher Lp(a).

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Combination of serum 5-S-cysteinyldopa, melanoma inhibitory activity and IL-8 improves the diagnostic accuracy of malignant melanoma compared with individual markers

et al. 2022

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Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient mortality. However, current clinical and histological variables show limited accuracy in diagnosis. Serum or urine level of 5-S-cysteinyldopa (5-S-CD) is a commonly used melanoma biomarker in Japan owing to its increased sensitivity compared with other melanoma markers. However, its use as a diagnostic marker has shown some limitations. Therefore, here we examined the combination of 5-S-CD with melanoma inhibitory activity, which showed sensitivity in detecting melanoma comparable with that of 5-S-CD, and interleukin-8, a cytokine linked with melanoma progression, in a cohort of Japanese patients with melanoma. Our results revealed that the triple combination of 5-S-CD, melanoma inhibitory activity, and interleukin-8 showed high diagnostic accuracy in detecting melanoma compared with each of the individual factors. Importantly, the triple marker showed specificity and utility in detecting early-stage melanoma. Our results suggest the utility of the triple marker as a diagnostic biomarker for melanoma patients.

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Imbalance between production and scavenging of hydroxyl radicals in patients maintained on hemodialysis

Abstract: There was an imbalance between .OH-producing ability and .OH-scavenging activity, in the ESRD patients, and this may be responsible for compromising the health of ESRD patients.

Cited by 7 publications

References 19 publications

Serum Levels of Pigmentation Markers Are Elevated in Patients Undergoing Hemodialysis

Serum Levels of Pigmentation Markers Are Elevated in Patients Undergoing Hemodialysis

Oxidized low‐density lipoprotein and lipoprotein(a) levels in chronic kidney disease patients under hemodialysis: Influence of adiponectin and of a polymorphism in the apolipoprotein(a) gene

Combination of serum 5-S-cysteinyldopa, melanoma inhibitory activity and IL-8 improves the diagnostic accuracy of malignant melanoma compared with individual markers

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