Imbalance between matrix metalloproteinases (MMP-9 and MMP-2) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in acute respiratory distress syndrome patients

Lanchou, Jérôme; Corbel, M; Tanguy, M.; Germain, Nicolas; Boichot, Elisabeth; Théret, Nathalie; Clément, Bruno; Lagente, Vincent; Malledant, Yannick

doi:10.1097/01.ccm.0000048626.02184.f8

Cited by 100 publications

(77 citation statements)

References 27 publications

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“…During VILI, high airway pressures and volumes lead to cell stretch, causing epithelial damage and an inflammatory response within the lungs. Increased levels of MMPs have been documented in different models of acute lung injury (8,13,27) and in the special case of VILI (14,25). MMP-9 is one of the most studied MMPs.…”

Section: Discussionmentioning

confidence: 99%

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Albaiceta¹,

Gutiérrez‐Fernández²,

Parra³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionmentioning

confidence: 99%

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Albaiceta¹,

Gutiérrez‐Fernández²,

Parra³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Extracellular matrix degradation is a well-known feature of MMPs, some of which, especially MMP-2 and MMP-9, play important roles in the pathogenesis of certain pulmonary diseases (6,11,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(26)(27)(28). However, only a few studies in the literature have investigated the role of MMPs in pneumonia pathogenesis (6,(22)(23)(24)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

“…MMPs play an important role in the pathogenesis of several pulmonary diseases, such as chronic obstructive pulmonary disease (COPD) (14,15), cystic fibrosis (16,17), bronchiectasis (18,19), asthma (11,15), pulmonary fibrosis (20), adult respiratory distress syndrome (21), and pneumonia (6,(22)(23)(24)(25)(26)(27)(28). Higher levels and activities of MMP-8 and -9 have been detected in patients with hospital-acquired and ventilator-associated pneumonia (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Bircan¹,

Çakır²,

Kapulu³

et al. 2015

Turk J Med Sci

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Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP).Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre-and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography.Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and PSI scores. Posttreatment serum levels of MMP-9 and TIMP-1 were decreased after antibiotics (P = 0.0001 and P = 0.017, respectively). Conclusion:Although MMP-2, MMP-9, and TIMP-1 correlate with many poor prognostic factors, more studies are required to prove their possible role in predicting the severity of CAP.

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“…Nevertheless, imbalances in the MMP/TIMP system (i.e. lower levels of TIMPs and/or higher levels of MMPs) are involved in the pathogenesis of several diseases including rheumatoid arthritis , Katrib et al, 2003, Lanchou et al, 2003, Romas et al, 2002, Schulze et al, 2003, Yoshihara et al, 2000, which share several features with PDs, including the chronic nature of the inflammatory reaction and tissue destruction , Mercado et al, 2003.…”

Section: Periodontal and Pulpar Tissues Under Homeostatic Conditionsmentioning

confidence: 99%

The Role of Chemokines and Cytokines in the Pathogenesis of Periodontal and Periapical Lesions: Current Concepts

Garlet¹,

Aranha²,

Silveira³

et al. 2012

Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases

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Imbalance between matrix metalloproteinases (MMP-9 and MMP-2) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in acute respiratory distress syndrome patients

Cited by 100 publications

References 27 publications

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

The Role of Chemokines and Cytokines in the Pathogenesis of Periodontal and Periapical Lesions: Current Concepts

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