Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish

Jin, Cuiyuan; Luo, Ting; Zhu, Zhihong; Pan, Zihong; Yang, Jiajing; Wang, Qianqian; Fu, Zhengwei; Jin, Yuanxiang

doi:10.1016/j.cbpc.2017.08.007

Cited by 86 publications

(37 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study, we reported that acute exposure to high doses of IMZ (25, 50, and 100 mg/kg/day) induced gut microbiota dysbiosis and colonic inflammation in male ICR mice . More recently, we also observed that IMZ exposure not only resulted in microbiota dysbiosis in the gut, but also induced hepatic metabolism disorder in adult zebrafish . However, to the best of our limited knowledge, few studies have examined the effects of liver exposure at an environmental level and its observed subsequent influences.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Jin

Luo

et al. 2018

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

Imazalil (IMZ), which is a widely used fungicide, can accumulate in the body and threaten an animal's health. However, this fungicide has adverse effects on aquatic organisms and ultimately affects human health when it leaches into the environment. Our research tried to determine that if IMZ might cause liver damage and its potential to cause-related diseases. In this study, male adult C57BL/6 mice were exposed to 0.1, 0.5, or 2.5 mg/kg body weight IMZ in drinking water for 15 weeks. Then, we evaluated the liver damage at the physiological, biochemical, and transcriptome levels in mice after chronic IMZ exposure. We observed serious ballooning degeneration of hepatocytes in the IMZ-treated groups. And IMZ induced oxidative stress and caused the disorders of bile acid metabolism in mice. In addition, the transcriptome data showed that IMZ has substantial influence on several pathways, including metabolic pathways for drug metabolism, RNA transport, and bile secretion. We further confirmed that the mRNA expression of the key genes involved in oxidative stress and bile acid metabolism were changed of mice exposed to IMZ. Our data suggested that chronic IMZ exposure could induce hepatotoxicity in mice at the physiological, biochemical, and transcriptome levels.

show abstract

Section: Discussionmentioning

confidence: 97%

“…According to our previous studies, IMZ induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder in zebrafish . In fact, the liver plays a very important role in regulating physiology.…”

Section: Introductionmentioning

confidence: 93%

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Jin

Luo

et al. 2018

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies have demonstrated the association between gut microbiome toxicity and pesticide exposure. For example, the fungicide imazalil changed the composition of gut microbiome in zebrafish and mice [57,58]. Of interest, a recent study showed that the mouse gut microbiome was perturbed by 13 weeks of diazinon exposure (4 ppm) [13].…”

Section: Pesticidesmentioning

confidence: 99%

Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases

Chi

Bodnar

et al. 2020

Toxics

View full text Add to dashboard Cite

The human gut microbiome can be easily disturbed upon exposure to a range of toxic environmental agents. Environmentally induced perturbation in the gut microbiome is strongly associated with human disease risk. Functional gut microbiome alterations that may adversely influence human health is an increasingly appreciated mechanism by which environmental chemicals exert their toxic effects. In this review, we define the functional damage driven by environmental exposure in the gut microbiome as gut microbiome toxicity. The establishment of gut microbiome toxicity links the toxic effects of various environmental agents and microbiota-associated diseases, calling for more comprehensive toxicity evaluation with extended consideration of gut microbiome toxicity.

show abstract

“…Imazalil (1-[2-(2,4-dichlorophenyl)-2(2-propenyloxy)ethyl]-1H-imidazole: IMZ) is a widely used pre- and post-harvest fungicide, detected in vegetables and fruits as well as in water and sludge [ 83 , 84 , 85 , 86 ]. Jin et al [ 87 ] investigated the consequences of IMZ exposure on male adult zebrafish exposed for 1, 7, and 21 days at IMZ concentrations of 100 and 1000 µg/L ( Table 2 ). The secretion of mucus in the gut, qualitatively characterized with AB-PAS staining, was decreased when the zebrafish were exposed to 1000 µg/L IMZ for 21 days ( Table 2 ).…”

Section: Effects Of Environmental Pollutants and Food Additives Onmentioning

confidence: 99%

Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives

et al. 2018

View full text Add to dashboard Cite

Synthetic chemicals (environmental pollutants, food additives) are widely used for many industrial purposes and consumer-related applications, which implies, through manufactured products, diet, and environment, a repeated exposure of the general population with growing concern regarding health disorders. The gastrointestinal tract is the first physical and biological barrier against these compounds, and thus their first target. Mounting evidence indicates that the gut microbiota represents a major player in the toxicity of environmental pollutants and food additives; however, little is known on the toxicological relevance of the mucus/pollutant interplay, even though mucus is increasingly recognized as essential in gut homeostasis. Here, we aimed at describing how environmental pollutants (heavy metals, pesticides, and other persistent organic pollutants) and food additives (emulsifiers, nanomaterials) might interact with mucus and mucus-related microbial species; that is, “mucophilic” bacteria such as mucus degraders. This review highlights that intestinal mucus, either directly or through its crosstalk with the gut microbiota, is a key, yet underestimated gut player that must be considered for better risk assessment and management of environmental pollution.

show abstract

Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish

Cited by 86 publications

References 55 publications

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases

Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives

Contact Info

Product

Resources

About