Imatinib intermediate as a two in one dual channel sensor for the recognition of Cu²⁺and I⁻ions in aqueous media and its practical applications

Abstract

An imatinib intermediate, 6-methyl-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diaminepyridopyrimidotoluidine (PPT-1), was developed for the colorimetric sensing of Cu(2+) ions in aqueous solution. With Cu(2+), the receptor PPT-1 showed a highly selective naked-eye detectable color change from colorless to red over the seventy other tested cations. The colorimetric sensing ability of PPT-1 was successfully utilized in the preparation of test strips and supported silica for the real samples analysis to detect Cu(2+) ions from 100% aqueous environment. Moreover, the iodide-sensing ability of receptor PPT-1 was explored among the ten examined anions.

A new multifunctional 1, 10-phenanthroline based fluorophore for anion and cation sensing

“…The chemosensor 1, the 1:2 species and 1:1 species were optimized by DFT method and in order to further understand the behaviour of Cu 2+ , Zn 2+ and I -ions with the chemosensor 1, DFT calculations have been carried out. The structural optimization of the chemosensor 1 and its 1·Cu 2+ /Zn 2+ /I -complexes was done using the Gaussian 03 package adopting the exchange correlation function B3LYP,and the basis sets 6-31G(d,p) (for C, H, N and O atoms) and LANL2DZ ( for Cu, Zn and I atoms) [11,30]. The optimized structures of the fluorophore 1 and its 1·Cu 2+ /Zn 2+ / I -complexes are shown in figure S6.…”

“…The Cu 2+ ions, in addition to its third highest abundance in the human body, plays an important role in various physiological processes such as hemoglobin biosynthesis, bone development, dopamine production, and nerve function regulation [30]. On the other hand, over accumulations of copper produces severe or lethal intoxications [31-32].…”

A uracil nitroso amine based colorimetric sensor for the detection of Cu2+ions from aqueous environment and its practical applications

“…Herein, as a part of our ongoing research on chemosensors, [32][33][34][35] we have developed a simple and easy to prepare colorimetric chemosensor, namely the uracil nitroso amine derivative UNA-1 (Scheme 1), which can be used for the highly selective and sensitive recognition of Cu 2+ ions. This chemosensor gives a visual color change from colorless to clear dark yellow allowing for the naked-eye detection of Cu 2+ .…”

Novel 1,10-phenanthroline - di-2-picolylamine scaffold as a selective chemosensor for copper and cyanide ions

“…The structural optimizations of 1 and its 1.Cu 2+ complex were carried using the Gaussian 03 package adopting the exchange correlation function B3LYP and the basis sets 6-31G (d,p) (for C, H, N and O atoms) and LANL2DZ (for Cu atoms) [34,35]. The optimized structures of 1 and its 1.…”