Imatinib in the Treatment of Chronic Myeloid Leukemia in Children and Adolescents is Effective and well-tolerated. Report of the Polish Pediatric Study Group for Treatment of Leukemias and Lymphomas
Abstract:Background. Chronic myeloid leukemia (CML) constitutes only 2-3% of all leukemias in pediatric patients. Philapelphia chromosome and BCR-ABL fusion are genetic hallmarks of CML, and their presence is crucial for targeted molecular therapy with tyrosine kinase inhibitors (TKIs), which replaced hematopoietic stem cell transplantation (HSCT) as a standard first-line therapy. The disease in pediatric population is rare, and despite molecular and clinical similarities to CML in adults, different approach is needed,… Show more
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