Imagining future events in patients with unilateral temporal lobe epilepsy

Lechowicz, Meryn; Miller, Laurie A.; Irish, Muireann; Addis, Donna Rose; Mohamed, Armin; Lah, Sunčica

doi:10.1111/bjc.12107

Cited by 11 publications

(10 citation statements)

References 85 publications

(92 reference statements)

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“…The finding of reduced episodic memory is in accordance with the previous studies, which have reported decreased episodic memory function in chronic TLE (47)(48)(49)(50). As far as we know, no other study has explored experiential aspects of episodic memory functions in newly diagnosed patients with TLE.…”

Section: Phenomenological Aspects Of Episodic Memorysupporting

confidence: 91%

Episodic Memory Dysfunction and Effective Connectivity in Adult Patients With Newly Diagnosed Nonlesional Temporal Lobe Epilepsy

et al. 2022

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ObjectiveEpilepsy is associated with both changes in brain connectivity and memory function, usually studied in the chronic patients. The aim of this study was to explore the presence of connectivity alterations measured by EEG in the parietofrontal network in patients with temporal lobe epilepsy (TLE), and to examine episodic memory, at the time point of diagnosis.MethodsThe parietofrontal network of newly diagnosed patients with TLE (N = 21) was assessed through electroencephalography (EEG) effective connectivity and compared with that of matched controls (N = 21). Furthermore, we assessed phenomenological aspects of episodic memory in both groups. Association between effective connectivity and episodic memory were assessed through correlation.ResultsPatients with TLE displayed decreased episodic (p ≤ 0.001, t = −5.18) memory scores compared with controls at the time point of diagnosis. The patients showed a decreased right parietofrontal connectivity (p = 0.03, F = 4.94) compared with controls, and significantly weaker connectivity in their right compared with their left hemisphere (p = 0.008, t = −2.93). There were no significant associations between effective connectivity and episodic memory scores.ConclusionsWe found changes in both memory function and connectivity at the time point of diagnosis, supporting the notion that TLE involves complex memory functions and brain networks beyond the seizure focus to strongly interconnected brain regions, already early in the disease course. Whether the observed connectivity changes can be interpreted as functionally important to the alterations in memory function, it remains speculative.

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Section: Phenomenological Aspects Of Episodic Memorysupporting

confidence: 91%

Episodic Memory Dysfunction and Effective Connectivity in Adult Patients With Newly Diagnosed Nonlesional Temporal Lobe Epilepsy

et al. 2022

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“…An intimate link between autobiographical memory and prospection is supposed on the basis of studies of amnestic patients in whom prospection is impaired [62], and the widespread recruitment of the autobiographic memory network during prospection [63] (Figure 1). The only study on prospective ability in epilepsy to date found that relative to healthy controls (n=20), people with unilateral TLE (n=20) generate less details when asked to describe potential autobiographical future events [64]. Although only preliminary data, these findings may indicate that assessment of a patient's prospective ability is clinically relevant to informed consent.…”

Section: Innovative Forms Of Memory Assessment In Epilepsymentioning

confidence: 92%

Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account

Rayner

Tailby

2017

Curr Neurol Neurosci Rep

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Some implications of a network conceptualisation of epilepsy include a need for more widespread cognitive phenotyping in epilepsy; recognition that memory disorders in epilepsy can be multi-determined, including by non-structural factors; deeper consideration given to the neurodevelopmental context in which memory problems emerge; the utility of new methods to characterise memory impairments in epilepsy; and a call for greater recognition of the close interrelationships between memory comorbidities and psychiatric symptoms in epilepsy. Memory disorder significantly worsens the quality of life of people with epilepsy, underscoring the importance to patient wellbeing of giving due consideration to the up-to-date neuropsychological practises outlined in this review.

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“…For example, studies that have used the AI to compare healthy older adults with young adults consistently show that older adults produce fewer internal/episodic details and more external/semantic details for both remembered past events and imagined future events, suggesting a common role of episodic memory in both event types (for review of early studies, see 16, and for recent and related evidence, see 5, 17–21). Reductions in episodic detail for both past and future events using the AI and related procedures have also been documented in various patient populations, including in recent studies of patients with depression (22), post-traumatic stress disorder (23), amnesic syndrome (24–27; but see 28 for relatively preserved future imagining in amnesics), Alzheimer’s disease (29–30), unilateral temporal lobe epilepsy (31), schizophrenia (32), prefrontal lesions (33), and long-term opiate users (34). …”

Section: Mechanisms Of Episodic Future Thinkingmentioning

confidence: 99%

Episodic future thinking: mechanisms and functions

Schacter

Benoit

Szpunar

2017

Current Opinion in Behavioral Sciences

539

421

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Episodic future thinking refers to the capacity to imagine or simulate experiences that might occur in one’s personal future. Cognitive, neuropsychological, and neuroimaging research concerning episodic future thinking has accelerated during recent years. This article discusses research that has delineated cognitive and neural mechanisms that support episodic future thinking as well as the functions that episodic future thinking serves. Studies focused on mechanisms have identified a core brain network that underlies episodic future thinking and have begun to tease apart the relative contributions of particular regions in this network, and the specific cognitive processes that they support. Studies concerned with functions have identified several domains in which episodic future thinking produces performance benefits, including decision making, emotion regulation, prospective memory, and spatial navigation.

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Imagining future events in patients with unilateral temporal lobe epilepsy

Cited by 11 publications

References 85 publications

Episodic Memory Dysfunction and Effective Connectivity in Adult Patients With Newly Diagnosed Nonlesional Temporal Lobe Epilepsy

Episodic Memory Dysfunction and Effective Connectivity in Adult Patients With Newly Diagnosed Nonlesional Temporal Lobe Epilepsy

Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account

Episodic future thinking: mechanisms and functions

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