Imaging trait anxiety in high anxiety F344 rats: Focus on the dorsomedial prefrontal cortex

Prinssen, Eric; Nicolas, Laurent B.; Klein, Steffen; Grundschober, Christophe; López-López, Cristina; Keßler, Melanie; Bruns, Andreas; Kienlin, Markus von; Wettstein, Joseph G.; Moreau, Jean‐Luc; Risterucci, Céline

doi:10.1016/j.euroneuro.2011.11.001

Cited by 8 publications

(1 citation statement)

References 63 publications

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“…The specificity of our findings is also indirectly corroborated by the results of recent neuroimaging studies where different inbred rat strains (not showing alcohol preference) were compared. For example, Prinssen and colleagues (Prinssen et al, 2012) reported increased perfusion in the cingulate cortex and hippocampus and decreased perfusion in the thalamus of F344 rats compared to control Sprague-Dawley rats, a pattern of alterations that is substantially different from the one seen in the present study. Similarly, Sawiak and colleagues (Sawiak et al, 2012) used VBM to test morphometric differences in the brain of high- and low-impulsivity rats (e.g.…”

Section: 4 Discussioncontrasting

confidence: 82%

Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction

et al. 2013

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Alcohol abuse is associated with long-term reductions in fronto-cortical volume and limbic metabolism. However, an unanswered question in alcohol research is whether these alterations are the sole consequence of chronic alcohol use, or contain heritable contributions reflecting biological propensity toward ethanol addiction. Animal models of genetic predisposition to alcohol dependence can be used to investigate the role of inborn brain abnormalities in the aetiology of alcoholism. Here we used magnetic resonance imaging (MRI) in e Marchigian Sardinian (msP) alcohol-preferring rats to assess the presence of inherited structural or functional brain alterations. Alcohol-naïve msP (N=22) and control rats (N=26) were subjected to basal cerebral blood volume (bCBV) mapping followed by voxel-based morphometry (VBM) of gray matter and tract-based spatial statistics mapping of white matter fractional anisotropy. msP rats exhibited significantly reduced bCBV, an established marker of resting brain function, in focal cortico-limbic and thalamic areas, together with reduced gray matter volume in the thalamus, ventral tegmental area, insular and cingulate cortex. No statistically significant differences in fractional anisotropy were observed between groups. These findings highlight the presence of inborn gray matter and metabolic abnormalities in alcohol-naïve msP rats, the localization and sign of which are remarkably similar to those mapped in abstinent alcoholics and subjects at high risk for alcohol dependence. Collectively, these results point for a significant role of heritable neurofunctional brain alterations in biological propensity toward ethanol addiction, and support the translational use of advanced imaging methods to describe the circuital determinants of vulnerability to drug addiction.

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Section: 4 Discussioncontrasting

confidence: 82%