Imaging the structural connectome with hybrid diffusion MRI-microscopy tractography
Silei Zhu,
Istvan N. Huszar,
Michiel Cottaar
et al.
Abstract:Neuroanatomical tract tracing methods are fundamental in providing “gold standard” estimates of brain connectivity. However, tracer methods cannot be performed in humans and even in animals, we can only study projections from typically one or two injection sites per animal sacrificed. Orientation-sensitive microscopy techniques such as PLI provide an alternative where they can visualise detailed fibre orientations at the micron-scale across the whole brain. However, these methods are often most informative on … Show more
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