Imaging the Postdeposition Dispersion of an Inhaled Surfactant Aerosol

Abstract

Our results lack statistical significance, but suggest that inhaled calfactant increased peripheral clearance, due to either surfactant-based dispersion or mucociliary effects. Further studies are needed to define the potential for low surface tension carriers to improve drug delivery.

Aerosol Route to Administer Teicoplanin in Mechanical Ventilation: In Vitro Study, Lung Deposition and Pharmacokinetic Analyses in Pigs

“…(19) The VMD of 2.5 lm that we observed is consistent with the peripheral distribution of particles assessed by lung scintigraphy (for liquid water droplets VMD is approximately equal to mass median aerodynamic diameter -MMAD -). (20) In the present study, the ventilator setting and component were not totally optimized for aerosol delivery. (10) We chose to use usual ventilator settings in order to avoid iterative ventilator setting modifications, and simplified the nebulization process for future clinical practice.…”

Delivery and Performance of Surfactant Replacement Therapies to Treat Pulmonary Disorders

“…This investigation has been confirmed by Corcoran et al, who exploited a radioscintigraphy technique to track the deposition and redistribution of an inhaled drug analog administered to cystic fibrosis patients in a low-surface tension carrier [95]. Infasurf was employed and paired lung distribution comparisons were made with a size-matched saline aerosol control.…”

“…Aerodynamic forces are key in distributing aerosol therapeutics within the lungs. The correlation between air flows, aerosol mechanics, and aerosol deposition, which are well characterized in healthy lungs, become more complex in the setting of lung disease [95]. …”

Aerosolized Surfactants, Anti-Inflammatory Drugs, and Analgesics

“…Another study compared technetium-labeled aerosolized calfactant and saline in 8 subjects with cystic fibrosis and demonstrated similar distribution but with more rapid clearance of the technetium with the calfactant, suggesting that inhaled calfactant increased mucus clearance. 33 In an interventional study in 5 young adults with cystic fibrosis, nebulized whole-lung surfactant (Alveofact) was administered daily for 5 d and failed to show any improvement in FEV 1 or FVC. 34 In contradistinction, a single case report of nebulized Exosurf in a patient with presumed reperfusion injury after lung transplant showed rapid improvement in compliance and oxygenation.…”