Imaging the extent and location of spatiotemporally distributed epileptiform sources from MEG measurements

Abstract

Non-invasive MEG/EEG source imaging provides valuable information about the epileptogenic brain areas which can be used to aid presurgical planning in focal epilepsy patients suffering from drug-resistant seizures. However, the source extent estimation for electrophysiological source imaging remains to be a challenge and is usually largely dependent on subjective choice. Our recently developed algorithm, fast spatiotemporal iteratively reweighted edge sparsity minimization (FAST-IRES) strategy, has been shown to objectively estimate extended sources from EEG recording, while it has not been applied to MEG recordings. In this work, through extensive numerical experiments and real data analysis in a group of focal drug-resistant epilepsy patients’ interictal spikes, we demonstrated the ability of FAST-IRES algorithm to image the location and extent of underlying epilepsy sources from MEG measurements. Our results indicate the merits of FAST-IRES in imaging the location and extent of epilepsy sources for pre-surgical evaluation from MEG measurements.

Personalized Deep Learning based Source Imaging Framework Improves the Imaging of Epileptic Sources from MEG Interictal Spikes

“…When using sparse imaging methods for a higher spatial specificity value, the sensitivity could drop to 25%-40% [62]. Correctly estimating the extent of the sources objectively remains to be a challenging problem [11,68]. DeepSIF provides a reasonable balance between identifying the correct source regions and having spurious activations, as the geometric mean of the sublobar sensitivity and specificity is 87% and 78% respectively for PDeepSIF and GDeepSIF.…”

“…Gradiometers have the advantage of reducing the environmental noise during the recording [32], while a higher sensitivity for detecting mesial temporal spikes has been reported for magnetometers [36]. The influence of different sensor configurations on ESI methods remains to be an open question that worth exploring in future investigations [68,73].…”