Imaging the body with diffuse optical tomography

Boas, David A.; Brooks, Dana H.; Miller, Eric L.; DiMarzio, Charles A.; Kilmer, Misha E.; Gaudette, Richard J.; Zhang, Quan

doi:10.1109/79.962278

Cited by 643 publications

(469 citation statements)

References 92 publications

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“…We close by noting that the proposed method is applicable to other encephalographic modalities with linear superposition of activity, such as functional near infrared imaging (Boas et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

Linear Spatial Integration for Single-Trial Detection in Encephalography

Parra¹,

Alvino²,

et al. 2002

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Conventional analysis of electroencephalography (EEG) and magnetoencephalography (MEG) often relies on averaging over multiple trials to extract statistically relevant differences between two or more experimental conditions. In this article we demonstrate single-trial detection by linearly integrating information over multiple spatially distributed sensors within a predefined time window. We report an average, single-trial discrimination performance of A z Ϸ 0.80 and fraction correct between 0.70 and 0.80, across three distinct encephalographic data sets. We restrict our approach to linear integration, as it allows the computation of a spatial distribution of the discriminating component activity. In the present set of experiments the resulting component activity distributions are shown to correspond to the functional neuroanatomy consistent with the task (e.g., contralateral sensorymotor cortex and anterior cingulate). Our work demonstrates how a purely data-driven method for learning an optimal spatial weighting of encephalographic activity can be validated against the functional neuroanatomy.

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Section: Resultsmentioning

confidence: 99%

Linear Spatial Integration for Single-Trial Detection in Encephalography

Parra¹,

Alvino²,

et al. 2002

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“…Tomographic imaging with diffuse light, often referred to as optical diffusion tomography (ODT), is a novel biomedical imaging modality [1,2]. Although ODT was introduced more than a decade ago, efforts to bring it into the clinical environment are hampered by relatively low quality and spatial resolution of images.…”

Section: Introductionmentioning

confidence: 99%

Multiple projection optical diffusion tomography with plane wave illumination

Markel

Schotland

2005

Phys. Med. Biol.

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Abstract. We describe a new data collection scheme for optical diffusion tomography in which plane wave illumination is combined with multiple projections in the slab imaging geometry. Multiple projection measurements are performed by rotating the slab around the sample. The advantage of the proposed method is that the measured data can be much more easily fitted into the dynamic range of most commonly used detectors. At the same time, multiple projections improve image quality by mutually interchanging the depth and transverse directions, and the scanned (detection) and integrated (illumination) surfaces. Inversion methods are derived for image reconstructions with extremely large data sets. Numerical simulations are performed for fixed and rotated slabs.

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“…Surface and multispectral images have been used to assess epithelial tissue structure and physiology [1][2][3], brain function [4,5] or superficial redox potential [6]. Probing of hemoglobins deeper in tissue has been used in functional transillumination or reflectance imaging [7,8] or diffuse optical tomography [9][10][11][12][13][14]. Other techniques have exploited light polarization [15] or light interference [16,17].…”

mentioning

confidence: 99%

Shedding light onto live molecular targets

Weissleder

Ntziachristos

2003

Nat Med

1,763

1,319

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Abstract-Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infrared fluorochromes, development of targeted and activatable 'smart' imaging probes, engineered photoproteins and advances in photon migration theory and reconstruction. Together, these advances will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.

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Imaging the body with diffuse optical tomography

Cited by 643 publications

References 92 publications

Linear Spatial Integration for Single-Trial Detection in Encephalography

Linear Spatial Integration for Single-Trial Detection in Encephalography

Multiple projection optical diffusion tomography with plane wave illumination

Shedding light onto live molecular targets

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