“…Although many excellent reviews already exist in the image-based heart-modeling area, most of them are focused on just one or two specific aspects: for example, image acquisition and processing ( Weese et al, 2013 ; Lamata et al, 2014 ; Wang et al, 2015 ; Watson et al, 2018 ), hemodynamic flow simulations ( Tang et al, 2010 ; Mittal et al, 2016 ; Quarteroni et al, 2017 ; Zhong et al, 2018 ); electrical conduction and stimulation modeling ( Trayanova, 2011 , 2012 ; Tobon-Gomez et al, 2013 ; Lopez-Perez et al, 2015 ; Rodriguez et al, 2015 ; Beheshti et al, 2016 ; Gray and Pathmanathan, 2018 ; Ni et al, 2018 ); tissue mechanics computations ( Trayanova, 2011 , 2012 ; Sun et al, 2014 ; Wang et al, 2015 ; Chabiniok et al, 2016 ; Niederer et al, 2019a , b ), ventricular thrombosis ( Mittal et al, 2016 ) and the use of models in diagnostic procedures ( Tang et al, 2010 ; Trayanova, 2012 ). Whereas, the goal of this manuscript is to provide a brief introductory overview of the entire cardiovascular IBM for a non-expert audience, in order to increase the broader exposure of this exciting topic and its numerous potential applications: CAD, Arrhythmias, Heart Failure (HF), Left-Ventricular Assist Devices (LVAD) and Pathogenic Thrombosis/Embolism.…”