Imaging techniques in the evaluation of morbidity in schistosomiasis mansoni

Lambertucci, José Roberto; Silva, Luciana Cristina dos Santos; Andrade, Luciene Mota; Queiroz, Leonardo Campos de; Carvalho, Vinicius Tostes; Voieta, Izabela; Antunes, Carlos

doi:10.1016/j.actatropica.2008.07.009

Cited by 57 publications

(48 citation statements)

References 38 publications

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“…In Figure 1, [21][22][23][24] . All patients had three negative parasitological stool examinations by the Kato-Katz technique and they also reported previous treatment for schistosomiasis ranging from 2 to 5 years before being enrolled in the present investigation.…”

Section: Patientsmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. Methods: Sixty three patients (mean age 45.5±11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented >30mg/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. Results: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. Conclusions: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.

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Section: Patientsmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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“…It uses strong magnetic fi elds and non-ionizing radiation in the radio frequency range, in contrast to CT scans and traditional X-rays, which both use ionizing radiation. Contrast agents may be injected intravenously to enhance the appearance of blood vessels, tumors or infl ammation [36][37][38][39][40][41][42][43] . …”

Section: Magnetic Resonance Imaging In Hepatosplenic Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

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“…Totally, it may take 4-6 weeks for migration and maturation, depending on the response of the host and the species involved [8] . As a result of egg-induced chronic presinusoidal inflammation, fibrous material deposition and vascular destruction are induced, which is called "Symmer's pipe-stem fibrosis", indicating a periportal fibrosis without bridging and nodular formation [18] .…”

Section: The Ectopic Migration Of Adult Worms This Hypothesismentioning

confidence: 99%

“…Another reason is the sparse distribution of the eggs and a less intense periovular inflammatory reaction [5,8,18,26,27] . Zhou [28] has observed the schistosomula migration in the host, and reports that the schistosomula stay in pulmonary system before ectopic migration.…”

Section: Spinal Cord Schistosomiasis and The Pathway Of Vertebral Batmentioning

confidence: 99%

“…The lack of neuropathic symptoms of cerebral schistosomiasis may be due to the sparse distribution of eggs in the brain, or the less intense granulomatous reaction around the eggs than that during acute schistosomiasis [5,18,33] . As a result of the portal hypertension and the pathway of the vertebral venous Batson's plexus, it is easier to open the above-mentioned pathways by vascular anastomosis, and the eggs can easily reach the CNS via the artery system, either through the pulmonary arteriovenous anastomoses or portal venous anastomosis such as the azygos vein.…”

Section: Spinal Cord Schistosomiasis and The Pathway Of Vertebral Batmentioning

confidence: 99%

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Research development of the pathogenesis pathways for neuroschistosomiasis

Wang

Chen

et al. 2010

Neurosci. Bull.

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Abstract:The infection of the central nervous system (CNS) by schistosome may or may not have clinical manifestations.When symptomatic, neuroschistosomiasis (NS) is one of the most severe presentations of schistosome infection. Among the NS symptoms, cerebral invasion is mostly caused by Schistosoma japonicum (S. japonicum), and the spinal cord symptoms are mainly caused by S. mansoni or S. haematobium. There are 2 main pathways by which schistosomes cause NS: egg embolism and worm migration, via either artery or vein system, especially the valveless perivertebral Batson's plexus. The adult worm migrates anomalously through the above pathways to the CNS where they lay eggs. Due to the differences in species of schistosomes and stages of infection, mechanisms vary greatly. The portal hypertension with hepatosplenic schistosomiasis also plays an important role in the pathogenesis. Here the pathways through which NS occurs in the CNS were reviewed.

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Imaging techniques in the evaluation of morbidity in schistosomiasis mansoni

Cited by 57 publications

References 38 publications

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Research development of the pathogenesis pathways for neuroschistosomiasis

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