Imaging Skeletal Muscle by Magnetic Resonance Imaging (MRI)

Morris, Robert H.; Sale, Craig

doi:10.1007/978-1-0716-3315-1_3

Cited by 1 publication

(2 citation statements)

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“…Although providing the most reliable measurements, CT comes at a great cost, requires expertise to conduct and subjects volunteers to ionizing radiation [ 47 ]. Magnetic Resonance Imaging (MRI) is a non-invasive imaging method used to quantify skeletal muscle mass (cross-sectional area) and ‘quality’, which is commonly adopted due to its excellent accuracy and reproducibility [ 48 ]. However, the associated costs and expertise remain key limitations associated with MRI, as does the need to exclude volunteers/patients based on certain implants [ 48 ].…”

Section: Methods To Measure Muscle Massmentioning

confidence: 99%

“…Magnetic Resonance Imaging (MRI) is a non-invasive imaging method used to quantify skeletal muscle mass (cross-sectional area) and ‘quality’, which is commonly adopted due to its excellent accuracy and reproducibility [ 48 ]. However, the associated costs and expertise remain key limitations associated with MRI, as does the need to exclude volunteers/patients based on certain implants [ 48 ]. Dual-energy x-ray absorptiometry (DXA) is a surrogate method to measure muscle mass, providing highly precise and accurate measures of lean soft tissue, with appendicular lean soft tissue being used for the estimation of muscle mass [ 49 ].…”

Section: Methods To Measure Muscle Massmentioning

confidence: 99%

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Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies

Deane,

Piasecki,

Atherton

2024

Clinical Science

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Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular mechanisms contributing to the altered regulation of muscle protein balance during disuse have been investigated but rarely synthesised in the context of humans. This narrative review discusses human models of muscle disuse and the ensuing inversely exponential rate of muscle atrophy. The molecular processes contributing to altered protein balance are explored, with a particular focus on growth and breakdown signalling pathways, mitochondrial adaptations and neuromuscular dysfunction. Finally, key research gaps within the disuse atrophy literature are highlighted providing future avenues to enhance our mechanistic understanding of human disuse atrophy.

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Section: Methods To Measure Muscle Massmentioning

confidence: 99%