Imaging Reveals Optic Tract Degeneration in Hemianopia

Bridge, Holly; Jindahra, Panitha; Barbur, John L.; Plant, Gordon T.

doi:10.1167/iovs.10-5708

Cited by 79 publications

(72 citation statements)

References 13 publications

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“…20,21 More recently, resource to high-resolution magnetic resonance imaging revealed optic tract thinning in hemianopic patients. 22 The development of OCT technology allowed for an easy and non-invasive analysis of the retina and the optic disc. RNFL analysis and more recently the study of RGC layers have been used as potential methods in TRD research.…”

Section: Discussionmentioning

confidence: 99%

Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

Anjos

Vieira

Costa

et al. 2016

Neuro-Ophthalmology

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The purpose of this study is to evaluate the macular ganglion cell layer (GCL) and peripapillary retinal nerve fibre layer (RNFL) thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions using spectral-domain optical coherence tomography (SD-OCT). A prospective, case-control study of patients with unilateral PCA lesion was conducted in the neuro-ophthalmology clinic of Centro Hospitalar Lisboa Central. Macular and peripapillary SD-OCT scans were performed in both eyes of each patient. Twelve patients with PCA lesions (stroke group) and 12 healthy normal controls were included in this study. Peripapillary RNFL comparison between both eyes of the same subject in the stroke group found a thinning in the superior-temporal (p = 0.008) and inferior-temporal (p = 0.023) sectors of the ipsilateral eye and nasal sector (p = 0.003) of the contralateral eye. Macular GCL thickness comparison showed a reduction temporally in the ipsilateral eye (p = 0.004) and nasally in the contralateral eye (p = 0.002). Peripapillary RNFL thickness was significantly reduced in both eyes of patients with PCA compared with controls, affecting all sectors in the contralateral eye and predominantly temporal sectors in the ipsilateral eye. A statistically significant decrease in macular GCL thickness was found in both hemiretinas of both eyes of stroke patients when compared with controls (p < 0.05). This study shows that TRD may play a role in the physiopathology of lesions of the posterior visual pathway. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

Anjos

Vieira

Costa

et al. 2016

Neuro-Ophthalmology

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“…A more speculative explanation is trans-synaptic retrograde degeneration, a phenomenon controversially discussed for decades [31][32][33][34][35][36][37][38][39][40], induced by optic radiation damage causing retinal thinning detectable by OCT. In our study, the association between focal tissue destruction in the OR and thinning of the RNFL remained significant even when considering exclusively patients without a history of ON, indicating that retinal axonal degeneration in MS occurs partially independent of ON -a notion also supported by previous OCT studies [14][15][16]41].…”

Section: Discussionmentioning

confidence: 99%

Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning – an ultrahigh-field MR pilot study

et al. 2014

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“…1 A recent study, however, suggested that retrograde transsynaptic degeneration in human optic tract is functionally apparent as early as 18 months after cortical damage. 30 Addi- tionally, a long delay of structurally visible changes compared with more subtle functional alteration is another possibility. In fact, functional impediment of INL has been reported in both conditions.…”

Section: Discussionmentioning

confidence: 99%

Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

Sriram

Graham

Wang³

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (transsynaptic) mechanism of retinal damage in these diseases. In the present study we used optical coherence tomography to investigate retrograde retinal transsynaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. METHODS. Fifteen eyes of glaucoma patients with visual field defect limited to upper hemifield and 15 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were imaged using spectral-domain optical coherence tomography and compared with two groups of age-matched controls. Combined retinal ganglion cell layer/ inner plexiform layer (GCL/IPL) thickness and inner nuclear layer (INL) thickness were analyzed. RESULTS. In the glaucoma group there was a significant (P ϭ 0.0005) reduction of GCL/IPL thickness in the lower (affected) retina compared with normal controls; however INL thickness was not statistically reduced (P ϭ 0.49). In the MS group reduction of GCL/IPL thickness in both hemifields of ON eyes was also significant (P ϭ 0.0001 and P Ͻ 0.0001 for inferior and superior retina respectively). However, similar to the glaucomatous eyes, there was no significant reduction of INL thickness in both hemifields (P ϭ 0.25 and P ϭ 0.45). CONCLUSIONS. This study demonstrates no significant loss of INL thickness in parts of the retina with long-standing and severe loss of retinal ganglion cells. (Invest Ophthalmol Vis Sci.

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Imaging Reveals Optic Tract Degeneration in Hemianopia

Cited by 79 publications

References 13 publications

Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning – an ultrahigh-field MR pilot study

Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

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