Imaging performance of tiled solid-state detectors

Petrillo, M.; Ye, J.; Vesel, J.; Shao, L. G.; Wieczorek, H.; Goedicke, Andreas

doi:10.1109/nssmic.2004.1462720

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…As described above, the R1-M showed high efficiency, high-spatial resolution, high contrast and high count rate characteristics, as reported in previous works of other SSDs [1][2][3]. Moreover, the R1-M showed good uniformity and sufficient energy linearity from 70 to 170 keV.…”

Section: Discussionsupporting

confidence: 78%

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Basic performance and stability of a CdTe solid-state detector panel

et al. 2010

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Section: Discussionsupporting

confidence: 78%

“…The fine-energy resolution leads to better image contrast due to better scatter rejection. The SSDs also provide a pixelated structure easily that improves count rate capability and intrinsic spatial resolution [1,2].…”

Section: Introductionmentioning

confidence: 99%

Basic performance and stability of a CdTe solid-state detector panel

et al. 2010

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“…Although relative differences were small, volume sensitivity with the CZT at 27 cm radius was signi cantly lower than with body contouring. This may be due to higher dependency of effective spatial resolution from source-to-collimator distance compared to NaI detectors (37)(38)(39). Consequently, variation in detector distance among patients could add systemspeci c variance in quantitative accuracy.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of iodine-123-mIBG SPECT/CT quantification in neuroblastoma using CZT and NaI detectors

Rogasch¹,

Bluemel²,

Großer³

et al. 2020

Preprint

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Background In [ 123 I]mIBG SPECT/CT for neuroblastoma, lesion uptake quantification could improve therapy monitoring. This study compared quantitative accuracy of a CZT (WEHR45) and NaI (LEHR) system (GE Discovery 670). Methods Volume sensitivity VS hom was estimated from a homogenous cylindrical phantom (811 ml) acquired with body contour or fixed 27 cm detector radius. Relative accuracy of VS hom to retrieve true background activity concentration (AC) in an IEC body phantom was calculated. Maximum/peak contrast recovery (CR) of the sphere inserts used VS IEC estimated from the IEC phantom. In 16 children with 37 [ 123 I]mIBG SPECT/CTs (range, 1-6 per patient; CZT, 12; NaI, 25), normal organ SUVmean (liver r/l, spleen, myocardium, blood pool, spine, muscles) were calculated using VS hom and VS IEC . Iterative reconstruction (Q.Metrix) used resolution recovery with/without scatter correction (SC) by dual energy window (DEW; 159 ± 10% and 130 ± 10% keV). In 20 exams, metabolic tumor volume (MTV)*SUVmax changes of primary tumors were correlated with changes of MRI tumor volume in serial scans (Pearson). Results VS hom (cts * MBq -1 * s -1 ) using SC was slightly lower for 27 cm radius vs. body contour with CZT (48 vs. 50, p<0.001) but comparable with NaI (59 vs. 61, p=0.18). Relative error in IEC phantom AC based on VS hom for CZT vs. NaI was -1.3% vs. +4.1% with SC (p=0.22). Acquisition time reduction by 50% (CZT) showed similar VS hom and relative error. CRmax/peak overestimated true AC in largest spheres (diameter, 22-37 mm) with SC and underestimated it without SC. Average SUVmean in liver and myocardium of CZT vs. NaI patients were similar. In the remaining organs (high estimated scatter proportions of >60% [CZT] or >40% [NaI]), average SUVmean differed between CZT and NaI, and coefficient of variation was significantly higher in SC vs. non-SC with CZT. MTV*SUVmax changes correlated with MRI volume changes with r=0.62 (non-SC) or r=0.59 (SC). Conclusions In principle, both CZT and NaI allow quantification in [ 123 I]mIBG SPECT/CT, but quantitative accuracy remains limited if using DEW for SC due to effects from source geometry (e.g. phantoms and organs) on scatter. Detector radius and acquisition time showed minor effects. MTV*SUVmax changes might be surrogate of response to therapy.

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“…Clinical gamma cameras have been developed by tiling together dozens of these modular CdTe and CZT detectors to cover similar areas as a conventional Anger camera (Eisen et al ., 2002; Wagenaar et al ., 2003; Petrillo et al ., 2004). Smaller assemblies of modular CZT pixel detectors have been deployed for scintimammography (Mueller et al ., 2003; O’Connor et al ., 2006), where the higher energy resolution allows for narrower energy windows, reducing scatter from the torso.…”

Section: Advances In Semiconductor Readoutmentioning

confidence: 99%

SPECT detectors: the Anger Camera and beyond

2011

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The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous NaI(Tl) scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic.

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Imaging performance of tiled solid-state detectors

Cited by 7 publications

References 19 publications

Basic performance and stability of a CdTe solid-state detector panel

Basic performance and stability of a CdTe solid-state detector panel

Feasibility of iodine-123-mIBG SPECT/CT quantification in neuroblastoma using CZT and NaI detectors

SPECT detectors: the Anger Camera and beyond

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