Imaging patterns of wall thickening type of gallbladder cancer

Soundararajan, Raghuraman; Marodia, Yashi; Gupta, Pankaj; Rana, Pratyaksha; Chhabra, Manika; Kalage, Daneshwari; Dutta, Usha; Sandhu, Manavjit Singh

doi:10.5114/ceh.2022.122285

Cited by 10 publications

(4 citation statements)

References 66 publications

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“…Both benign and malignant gallbladder diseases may present with symptoms such as upper abdominal pain and jaundice, and distinguishing benign from malignant gallbladder diseases based solely on clinical symptoms is difficult ( 7 ). Accurate diagnosis of benign and malignant gallbladder wall thickening is particularly important for the appropriate treatment of patients, avoiding overtreatment of benign diseases and delays in the treatment of malignant tumors ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…With the continuous development of ultrasound technology, color Doppler flow imaging (CDFI) can display the blood flow status of lesions, improving the AC of gallbladder lesion diagnosis ( 6 ). Ultrasonographic features of gallbladder wall thickening in benign diseases usually exhibit diffuse symmetrical wall thickening, whereas ultrasonographic features of gallbladder wall thickening in malignant diseases usually involve focal asymmetrical thickening without a layered appearance, destruction of the gallbladder wall, or an indistinct interface with the adjacent liver parenchyma ( 9 , 11 ). In February 2022, the American journal “Abdominal Radiology” published the Gallbladder Reporting and Data System (GB-RADS) for risk stratification of gallbladder wall thickening detected on ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic performance of the gallbladder reporting and data system combined with color doppler flow imaging for gallbladder cancer in the Asian population

Wang,

Lv,

2024

Front. Oncol.

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PurposeEvaluating the performance of the Gallbladder Reporting and Data System (GB-RADS) combined with Color Doppler Flow Imaging (CDFI) for the diagnosis of gallbladder wall thickening disease in an Asian population.MethodsIn this study, the lesions were classified and the actual incidence rate of malignant tumors was calculated for each GB-RADS category, following the guidelines provided by GB-RADS. To evaluate the diagnostic performance of GB-RADS and GB-RADS combined with CDFI, we plotted Receiver Operator Characteristic (ROC) curves. The sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and accuracy (AC) were also calculated. Inter-observer agreement (IRA) between the two observers was assessed using Kappa values.ResultsThe incidence of malignancy risk for GB-RADS 2, 3, 4, and 5 was 9%, 12.5%, 72.2%, and 100%. The AUC for GB-RADS was 0.855 (95% CI: 0.800-0.900), with a sensitivity of 82.5%, a specificity of 84.6%, and an accuracy of 83.8%. The AUC of GB-RADS combined with CDFI was 0.965 (95% CI: 0.930-0.985), with a sensitivity of 96.2%, a specificity of 94.6%, and an accuracy of 95.2%. The AUC, sensitivity, specificity, and accuracy of GB-RADS combined with CDFI for diagnosing gallbladder malignancy were higher than those of GB-RADS alone, and the differences were statistically significant (all P < 0.05). The IRA was excellent between the two observers (Kappa = 0.870).ConclusionsGB-RADS combined with CDFI demonstrated excellent diagnostic accuracy when it comes to distinguishing various diseases that caused gallbladder wall thickening in the Asian population, which has good clinical value and can improve the detection rate of malignant tumors in patients with gallbladder wall thickening.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of the gallbladder reporting and data system combined with color doppler flow imaging for gallbladder cancer in the Asian population

Wang,

Lv,

2024

Front. Oncol.

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“…A gallbladder tumor is usually represented on imaging as focal or diffuse asymmetric mural thickening [ 10 , 24 ].…”

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confidence: 99%

“…The presence of symmetric wall thickening often indicates a benign origin, such as acute or chronic cholecystitis or adenomyomatosis [ 24 ].…”

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The Many Hidden Faces of Gallbladder Carcinoma on CT and MRI Imaging—From A to Z

Neculoiu,

Popa

et al. 2024

Diagnostics

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Gallbladder carcinoma represents the most aggressive biliary tract cancer and the sixth most common gastrointestinal malignancy. The diagnosis is a challenging clinical task due to its clinical presentation, which is often non-specific, mimicking a heterogeneous group of diseases, as well as benign processes such as complicated cholecystitis, xanthogranulomatous cholecystitis, adenomyomatosis, porcelain gallbladder or metastasis to the gallbladder (most frequently derived from melanoma, renal cell carcinoma). Risk factors include gallstones, carcinogen exposure, porcelain gallbladder, typhoid carrier state, gallbladder polyps and abnormal pancreaticobiliary ductal junction. Typical imaging features on CT or MRI reveal three major patterns: asymmetric focal or diffuse wall-thickening of the gallbladder, a solid mass that replaces the gallbladder and invades the adjacent organs or as an intraluminal enhancement mass arising predominantly from the gallbladder fundus. The tumor can spread to the liver, the adjacent internal organs and lymph nodes. Depending on the disease stage, surgical resection is the curative treatment option in early stages and adjuvant combination chemotherapy at advanced stages. The purpose of this scientific paper is to fully illustrate and evaluate, through multimodality imaging findings (CT and MRI), different presentations and imaging scenarios of gallbladder cancer in six patients and thoroughly analyze the risk factors, patterns of spread and differential diagnosis regarding each particular case.

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Dual-energy CT in differentiating benign gallbladder wall thickening from wall thickening type of gallbladder cancer

Reddy,

Gupta,

Gulati

et al. 2024

Eur Radiol

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Imaging patterns of wall thickening type of gallbladder cancer

Cited by 10 publications

References 66 publications

Diagnostic performance of the gallbladder reporting and data system combined with color doppler flow imaging for gallbladder cancer in the Asian population

Diagnostic performance of the gallbladder reporting and data system combined with color doppler flow imaging for gallbladder cancer in the Asian population

The Many Hidden Faces of Gallbladder Carcinoma on CT and MRI Imaging—From A to Z

Dual-energy CT in differentiating benign gallbladder wall thickening from wall thickening type of gallbladder cancer

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