Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality

Putman, Rachel K.; Gudmundsson, Gardar; Axelsson, Guðni; Hida, T.; Honda, Osamu; Araki, T.; Yanagawa, Masahiro; Nishino, Michiya; Miller, Edgar R.; Eiríksdóttir, Guðný; Guðmundsson, Elías F.; Tomiyama, Noriyuki; Honda, Haruyoshi; Rosas, IO; Washko, G.R.; Cho, M.H.; Schwartz, David; Gudnason, Villi; Hatabu, H.; Hunninghake, G.M.

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7142

Cited by 34 publications

(74 citation statements)

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“…Imaging findings characteristic of underlying fibrosis (eg, traction bronchiectasis, honeycombing) increase the odds of progression more than eightfold. 3 These findings support the distinction of ILAs in terms of both morphology (fibrotic vs nonfibrotic) and distribution (subpleural vs centrilobular). 4 The lack of standardized terminology hampers attempts to use ILAs in the clinical field.…”

supporting

confidence: 81%

“…Studies have provided a clear association between ILAs and an increased risk of histologic fibrosis, 2 an increased rate of pulmonary function decline, 5 and all-cause mortality. 3,5,6 The association between ILAs and the development of lung cancer has not been adequately investigated. In this issue of CHEST, Whittaker Brown et al 7 present data from the National Lung Cancer Screening Trial (NLST) regarding the risk of developing lung cancer in participants with ILAs.…”

mentioning

confidence: 99%

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Interstitial Lung Abnormalities

Tzilas

Bouros

2019

Chest

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supporting

confidence: 81%

mentioning

confidence: 99%

Interstitial Lung Abnormalities

Tzilas

Bouros

2019

Chest

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“…Most of these were in patients with an ILA at enrollment, although six relatives without an ILA at enrollment went on to develop an ILD (9). These rates of progression are substantially lower than observed in AGES (Age Gene/Environment Susceptibility)-Reykjavik study in which 73% of 327 patients progressed radiologically over five years (14).…”

Section: Yonis H Mortaza S Baboi L Mercatmentioning

confidence: 56%

Three Steps to Cure Pulmonary Fibrosis. Step 1: The Runaway Train or Groundhog Day?

Jenkins

2020

Am J Respir Crit Care Med

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“…This study included a total of 149 patients diagnosed with LS-SCLC who underwent rst-line treatment, of whom 56 (38%) had concomitant ILA. It has previously been reported that concomitant ILA was observed in about 10-20% of the patients included in trials concerning chronic obstructive pulmonary disease (the COPDGene study 5,8 , ECLIPSE Study 20 , and AGES-Reykjavik Study 21 ), a study of screening for lung cancer using low-dose helical CT scans (the National Lung Screening Trial 6,22 ), and a study to identify common factors or characteristics that contribute to cardiovascular disease (Framingham Heart Study) 7,16,19 . The proportion of patients with concomitant ILA in our study was substantially greater than in those previous studies.…”

Section: Discussionmentioning

confidence: 99%

Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer and Interstitial Lung Abnormalities

Kobayashi

Wakuda

Naito

et al. 2020

Preprint

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Purpose: Patients with lung cancer and interstitial lung disease treated with radiotherapy have been reported to be at a risk of developing radiation pneumonitis. However, the association between interstitial lung abnormalities (ILA) and radiation pneumonitis in patients with limited-stage small cell lung cancer (LS-SCLC) remains unclear. Furthermore, the prognosis is unclear for patients with SCLC and ILA treated with chemoradiotherapy. We investigated the impact of ILA on radiation pneumonitis and assessed the prognosis of patients with LS-SCLC and ILA treated chemoradiotherapy. Methods and materials: We retrospectively reviewed the medical records of 149 patients with LS-SCLC who received first-line treatment between January 2009 and December 2016. Results: In a univariate analysis, the patients with ILA showed a higher incidence rate of radiation pneumonitis compared with those without ILA (64% vs. 10%); multivariate analysis confirmed that ILA was significantly associated with the incidence of radiation pneumonitis. In the univariate analysis, patients with ILA showed poorer overall survival than those without ILA (median, 18.9 vs. 67.9 months). Multivariate analysis showed that ILA was a significant independent negative prognostic factor. However, the 2-year and 5-year survival rates for the patients with ILA treated with chemoradiotherapy were 36% and 26%, respectively; for those treated with chemotherapy alone were 8% and 0%, respectively.Conclusions: ILA was a predictive factor for radiation pneumonitis in patients with LS-SCLC treated with chemoradiotherapy. The prognosis of the patients with LS-SCLC and ILA was poor; however, some patients with ILA treated chemoradiotherapy achieved long-term survival.

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Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality

Cited by 34 publications

References 0 publications

Interstitial Lung Abnormalities

Interstitial Lung Abnormalities

Three Steps to Cure Pulmonary Fibrosis. Step 1: The Runaway Train or Groundhog Day?

Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer and Interstitial Lung Abnormalities

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