Imaging patients with glaucoma using spectral-domain optical coherence tomography and optical microangiography

Auyeung, Kris; Auyeung, Kelsey; Kono, Rei; Chen, Chieh Li; Zhang, Qinqin; Wang, Ke

doi:10.1117/12.2084004

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…1,2 Optical coherence tomography angiography (OCTA) is a non-invasive imaging technology that creates high-resolution images of vascular structures across the retina and optic nerve without intravenous contrast. [3][4][5] OCTA has shown diminished vessel density (VD) in the peripapillary and macular areas in glaucoma compared to healthy controls. [6][7][8] Moreover, this technology has added values to OCT (optical coherence tomography).…”

Section: Introductionmentioning

confidence: 99%

OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review

Miguel¹,

Silva

Breda

et al. 2021

Br J Ophthalmol

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Background/aimsOptical coherence tomography angiography (OCTA) allows the study of vessel density (VD). We intended to perform a systematic review of studies focusing on longitudinal changes in peripapillary and macular VD measurements in glaucoma.MethodsA search was performed across MEDLINE, Scopus, ISI Web of Science and Google Scholar, using the following query from inception until 20 September 2019: ((“optical coherence tomography angiography”[tiab]) OR (optical coherence tomography angiography[MeSH]) OR (“OCTA”[tiab]) OR (“OCT-A”[tiab]) OR (“angio-OCT”[tiab]) OR (“OCT- angiography”[tiab]) OR (“OCT-angio”[tiab]) OR (“OCT-angiographie”[tiab])) AND (glaucom*[tiab] OR glaucoma[MeSH]). Prospective studies that quantitatively assessed the longitudinal changes in VD in glaucoma with at least 3 months of follow-up were included.ResultsTen out of 4516 studies were included. The rate of VD change in glaucoma varied from 0.036/year to 1.08/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. Five studies assessed VD change after glaucoma surgery, obtaining variable results, ranging from a temporary VD decrease to increase after 3 months. Meta-analysis was not possible due to a wide variation in methods, measurements and region of VD.ConclusionOCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses.

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