Imaging of β-oxidation by static PET with 14(R,S)-[18F]-fluoro-6-thiaheptadecanoic acid (FTHA) in patients with advanced coronary heart disease

Schulz, G; Dahl, Juergen vom; Kaiser, Hartmut; Koch, Karl‐Christian; Sabri, Osama; Banneitz, L.; Cremerius, U.; Buell, U.

doi:10.1097/00006231-199612000-00010

Cited by 20 publications

(47 citation statements)

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“…This provides additional confirmation that PET is a reliable method in measuring myocardial [ 18 F]FTHA uptake. Furthermore, the estimated myocardial FFA uptake rates were concordant with the values reported from previous studies in animals (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) µmol 100 g -1 min -1 ) [1,23,24,25,26].…”

Section: Discussionsupporting

confidence: 88%

“…14(R,S)-[ 18 F]Fluoro-6-thia-heptadecanoic acid ([ 18 F]FTHA) has recently been used to study fatty acid metabolism in humans [5,6,7,8,9,10]. [ 18 F]FTHA has been used in determining skeletal muscle and myocardial fatty acid uptake rates [8,10], and these studies yielded consistent results with earlier FFA uptake measurements with various methods.…”

Section: Introductionmentioning

confidence: 77%

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14( R , S )-[ 18 F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle

Takala

Nuutila

Pulkki

et al. 2002

European Journal of Nuclear Medicine and Molecular Imaging

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14( R, S)-[(18)F]Fluoro-6-thia-heptadecanoic acid ([(18)F]FTHA) is a long-chain fatty acid substrate for fatty acid metabolism. [(18)F]FTHA has been used to study fatty acid metabolism in human heart and skeletal muscle. It has been suggested that the rate of radioactivity accumulation in the myocardium reflects the beta-oxidation rate of free fatty acids (FFAs). However, the net accumulation of FFAs in tissue always represents the sum of FFA oxidation and incorporation into triglycerides. The fraction of [(18)F]FTHA entering directly into mitochondria for oxidation has not been previously measured. Eight anaesthetized pigs were studied with [(18)F]FTHA and positron emission tomography (PET). Immediately after each PET experiment, tissue samples from myocardium and skeletal muscle were taken for the isolation of mitochondria and measurements of radioactivity accumulation, and for intracellular [(18)F]FTHA metabolite analysis. Fractional [(18)F]FTHA uptake rates were calculated both by graphical analysis of PET data and by measuring (18)F in the tissue samples. Fractional [(18)F]FTHA uptake rates based on the analysis of tissue samples were 0.56+/-0.17 ml g(-1) min(-1) and 0.037+/-0.007 ml g(-1) min(-1) for myocardium and skeletal muscle (mean +/- SD), respectively. The myocardial results obtained from the PET data (0.50+/-0.11 ml g(-1) min(-1)) were similar to the values obtained from the tissue samples ( r=0.94, P=0.002). We also found that 89%+/-23% (mean+/-SD, n=7) of the (18)F entered mitochondria in myocardium, as compared with only 36%+/-15% (mean+/-SD, n=7) in skeletal muscle. Intracellular [(18)F]FTHA metabolite analysis showed that a major part of [(18)F]FTHA is metabolized in the mitochondria in the heart. Our data suggest that ~89% of [(18)F]FTHA taken up by the heart enters mitochondria. This supports the hypothesis that [(18)F]FTHA traces FFA beta-oxidation in the heart. In contrast to this, only ~36% of [(18)F]FTHA accumulated in skeletal muscle appears to directly enter mitochondria; the majority is taken up by the other cell fractions, suggesting that in skeletal muscle [(18)F]FTHA traces FFA uptake but not specifically FFA beta-oxidation.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 77%

14( R , S )-[ 18 F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle

Takala

Nuutila

Pulkki

et al. 2002

European Journal of Nuclear Medicine and Molecular Imaging

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“…Myocardial uptake and retention tracked accordingly with changes in substrate delivery, blood flow and workload in animal models 35, 36. The effects of various diseases such as coronary artery disease and dilated cardiomyopathy on myocardial fatty acid metabolism have been evaluated with PET using this radiotracer 37, 38. However, uptake and retention of FTHA has been shown to be insensitive to the inhibition of β-oxidation by hypoxia reducing enthusiasm for this radiotracer to measure myocardial fatty acid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Radionuclide Imaging of Myocardial Metabolism

Peterson

Gropler

2010

Circ: Cardiovascular Imaging

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“…Thus, positronemitting fatty acid analogues such as [11] C-palmitate and [18] F-thiaheptadecanoic acid (FTHA) have been also used to assess myocardial viability. Although fatty acid oxidation is preserved in hibernating myocardium [23], the clinical results with these tracers have not been encouraging [24]. 11 C-acetate has, however, been used successfully [25].…”

Section: Imaging Techniques For Myocardial Viabilitymentioning

confidence: 99%

“…Thallium has been used extensively for identifying myocardial viability and hibernation; it was the-first tracer to be used for this purpose [20][21][22][23][24][25][26][27][28]. However, it has a number of unfavourable properties, such as a low-energy X-ray emission and a long half-life, leading to appreciable radiation exposure to patients.…”

Section: Imaging Techniques For Myocardial Viabilitymentioning

confidence: 99%

Diagnostic and imaging considerations: Role of viability

Senior

2006

Heart Fail Rev

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Left ventricular systolic dysfunction is a recognised feature of heart failure. In developed nations, the leading cause of left ventricular systolic dysfunction is coronary artery disease. Revascularisation is a treatment strategy for patients with predominant symptoms of heart failure and significant left ventricular dysfunction. Presence or absence of myocardial viability has been shown to affect outcome after revascularisation. There are various techniques to assess myocardial viability. However, limitations of current literature, lack of completed randomised trials and high peri-procedural trials create significant uncertainty about the optimal strategy. This review focuses on the role of non-invasive testing for myocardial viability in patients with left ventricular systolic dysfunction and heart failure and also outlines the pros and cons of each technique.

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Imaging of β-oxidation by static PET with 14(R,S)-[18F]-fluoro-6-thiaheptadecanoic acid (FTHA) in patients with advanced coronary heart disease

Cited by 20 publications

References 0 publications

14( R , S )-[ 18 F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle

14( R , S )-[ 18 F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle

Radionuclide Imaging of Myocardial Metabolism

Diagnostic and imaging considerations: Role of viability

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