Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells

Xu, Ning; Piao, Mingxing; Arkin, Kamile; Ren, Lei; Zhang, Jinyu; Hao, Jiawei; Zheng, Yuxin; Shang, Qianqian

doi:10.1016/j.talanta.2019.04.021

Cited by 19 publications

(10 citation statements)

References 22 publications

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“…As can be seen in Figure 1, the traditional QDs containing the core of CdX (CdTe, CdSe or CdS) are considered to be the best QDs for bioimaging (Oh et al, 2016; Xu et al, 2019). However, the results of recent researches demonstrate the high toxicity of these kinds of QDs due to their release of Cd ions (Wu, He, et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

Huang

Tang

2020

J of Applied Toxicology

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Quantum dots (QDs), as one of the emerging nanomaterials, have been widely studied by scientists due to their advantages and potential in bioimaging, especially cell imaging. Cadmium (Cd)‐based QDs, which have the best photoluminescence property, have received widespread attention. However, due to the obvious toxicity problem of these QDs, their cell imaging application is hindered. Recently, the emergence of Cd‐free‐metal and metal‐free QDs with lower toxicity makes people consider that Cd‐based QDs may be substituted by these QDs. However, problems of these QDs in cytotoxicity also cannot be ignored. Some reports claimed that their prepared emerging QDs for cell imaging were low toxicity, but there still exist up‐regulation of oxidative stress, inflammation, and apoptosis from other reports. And, up to now, few reports have separately summarized and discussed the issues of cell imaging and cytotoxicity of different types of QDs. Therefore, in this review, we classify QDs as following three types, Cd‐based, Cd‐free‐metal and metal‐free QDs, focus on the cell, the essential unit of life, discuss cell imaging application and cytotoxicity of QDs, and finally elucidate main mechanisms of cytotoxicity respectively. This review provides reference for the toxicity evaluation of QDs and highlights the potential cytotoxicity of Cd‐free QDs.

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Section: Introductionmentioning

confidence: 99%

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

Huang

Tang

2020

J of Applied Toxicology

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“…Therefore, the sizes of QDs (>8 nm) in the present study might be too large for P‐gp to pump them out. Instead, they cross the cell membrane by endocytosis and exocytosis pathway, therefore disrupting the fluidity of cell membrane (Xing et al, ) and suppressing the expression of ABC transporters (Xu et al, ). Therefore, a systemic evaluation of the effects of QD sizes on their interaction with ABC transporters is necessary, which would further reveal the possible reasons for our present results.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the sizes of QDs (>8 nm) in the present study might be too large for P-gp to pump them out. Instead, they cross the cell membrane by endocytosis and exocytosis pathway, therefore disrupting the fluidity of cell membrane (Xing et al, 2018) and suppressing the expression of ABC transporters (Xu et al, 2019).…”

Section: Altered Expression Of P-gp and Mirnas Caused By Cdcl 2 Andmentioning

confidence: 99%

MicroRNA‐mediated suppression of P‐glycoprotein by quantum dots in lung cancer cells

Sun

Zhang

Yin

et al. 2019

J of Applied Toxicology

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The interactions between adenosine triphosphate‐binding cassette (ABC) transporters and nano‐sized materials are attracting increasing attention, due to their great potential in overcoming the multidrug resistance (MDR) phenomena in cancer treatment. However, the inner mechanisms involved in the interactions are largely unknown. In this study, two commercial quantum dots (QDs), CdSe/ZnS‐MPA and CdSe/ZnS‐GSH, were tested for their interactions with P‐glycoprotein (P‐gp), as well as the relating mechanisms in lung cancer (A549) cells. Both QDs significantly suppressed the gene and protein expressions of P‐gp in A549 cells. To explain this, the gene expressions of nine relating microRNAs (miRNAs) were evaluated. The results indicated a shared up‐regulation of miR‐34b and miR‐185 by both QDs. Furthermore, mimics and inhibitors of miR‐34b and miR‐185 significantly enhanced and suppressed the gene and protein expressions of P‐gp, respectively, confirming the modulatory function of these two miRNAs on P‐gp. Interestingly, expressions of both miRNAs were suppressed during treatment with Cd2+ and doxorubicin, which induced the expression of P‐gp, indicating the universality of these miRNAs‐related mechanisms. Thus, as miR‐34b and miR‐185 participated in the suppression of P‐gp functions in A549 cells they could be interesting targets for the treatment of lung cancer.

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“…Indeed, Cd is also effective against HCC in experimental animals ( 6 – 8 ) and in cultured liver tumor SMMC cells and their xenografts ( 9 , 10 ). Cd-coordinated supramolecules, such as Cd-pyrithione ( 11 ), Cd telluride/Cd sulfide ( 12 , 13 ), Cd-coordinated thiacalix arene tetrasulfate ( 14 ), Cd-thiocarbodiazone complex ( 15 ), Cd in combination with human second mitochondria-derived activator of caspase ( 16 ) and a novel binuclear hydrazone-based Cd(II) complex ( 17 ), have shown potential antitumor effects against chemoresistant malignant cells.…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects of cadmium against diethylnitrosamine‑induced liver tumors in mice

Nie

Huang

et al. 2021

Oncol Lett

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Cadmium (Cd) has been reported to exhibit antitumor effects against chemically induced liver tumors. However, the antitumor effects of Cd are not completely understood. Metallotherapy, the use of a toxic metal to attack liver tumors, could be a viable strategy. In the present study, 8-week old, male, C57BL/6 mice were administered injections of diethylnitrosamine (DEN) (90 mg/kg, and then 50 mg/kg 2 weeks later), followed by liver tumor promotion with carbon tetrachloride. Cadmium chloride was administered in the drinking water (1000 ppm) from 21–40 weeks after DEN initiation. Body weights were recorded and liver tumor formation was monitored via ultrasound. At the end of experiments, livers were removed, weighed, and the tumor incidence, tumor numbers and tumor size scores were recorded. Liver histology and metallothionein (MT) immunostaining were performed. After DEN injection, animal body weight decreased, and then slowly recovered with time. Cd treatment did not affect animal body weight gain. Ultrasound analysis detected liver tumors 35 weeks after DEN injection, and the mice were necropsied at 40 weeks. Liver/body weight ratios increased in the DEN and DEN + Cd groups. Cd treatment decreased the tumor incidence (71 vs. 17%), tumor numbers (15 vs. 2) and tumor scores (22 vs. 3) when compared with the DEN only group. Histopathology showed hepatocyte degeneration in all groups, and immunohistochemistry showed MT-deficiency in the liver tumors, while MT staining was intensified in the surrounding tissues. Reverse transcription-quantitative PCR showed increases in α-fetoprotein level in DEN-treated livers, and increases in MT-2 and tumor necrosis factor α (TNFα) levels in Cd-treated livers. Thus, it was concluded that Cd is effective in the suppression of DEN-induced liver tumors, and that the mechanisms may be related to MT-deficiency in tumors and the induction of TNFα to kill tumor cells.

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Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells

Cited by 19 publications

References 22 publications

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

Research advance on cell imaging and cytotoxicity of different types of quantum Dots

MicroRNA‐mediated suppression of P‐glycoprotein by quantum dots in lung cancer cells

Antitumor effects of cadmium against diethylnitrosamine‑induced liver tumors in mice

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