Imaging of Tuberculosis in Resource-Limited Settings

Pomykala, Kelsey L.; Desai, Ishita; Jardon, Meghan; Naik, Priyanka; Pool, Kara‐Lee

doi:10.1007/s40134-019-0335-7

Cited by 3 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…POCUS is the most efficient to detect primarily Abdominal TB (abdominal lymphadenopathy, splenic microabscess, ascites), then to screen for pleural TB and pericardial TB 24 , 29 . It is relatively useless to detect other forms of EPTB (such as meningeal or central nervous system TB, osteoarticular TB) 30 .…”

Section: Discussionmentioning

confidence: 99%

Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique

Nacarapa¹,

Munyangaju²,

Osório

et al. 2022

Sci Rep

View full text Add to dashboard Cite

In resource-limited settings, point-of-care ultrasound (POCUS) has great potential to support the timely diagnosis of extrapulmonary tuberculosis (EPTB). We aim to determine the in-hospital mortality due to EPTB according to clinical and POCUS features and risk factors in newly diagnosed patients hospitalized for EPTB in Chókwè district, Mozambique. We analyzed routinely collected data from paper medical files and electronic POCUS records of EPTB in infected patients aged 15 years or older and admitted to Carmelo Hospital of Chókwè from 2016 to 2020. Kaplan–Meier survival curves and adjusted Cox regression analyses were used to model predictors of mortality and time to death. The 390 included in-patients with EPTB and POCUS data contributed a total of 6240 in-hospital person-days of observation. The overall mortality rate was 2.16 per 100 person-days. Adjusted Cox regression showed a higher risk of death in those with abdominal tenderness (adjusted hazard ratio [aHR] 1.61, 95% confidence interval [CI] 1.00–2.82, p = 0.050), antiretroviral treatment (ART) for more than 90 days (aHR 4.03, 95% CI 1.50–10.78, p = 0.006), and mixed patterns on kidney POCUS (aHR 2.91, 95% CI 1.38–6.10, p = 0.005). An optimal immunovirological response to ART was a protective factor against death [aHR] 0.12, 95% CI 0.04–0.35, p < 0.001). Variables associated with an increased risk of death were male gender, abdominal pain, ART for more than three months (with immunovirological failure or non-response to ART) and having a mixed pattern of kidney POCUS characteristics. Early detection of these risk factors may have a direct impact on reducing TB mortality, and the POCUS approach as a complementary diagnostic method for EPTB provides a simple, feasible and affordable intervention in resource-limited settings like Mozambique.

show abstract

Section: Discussionmentioning

confidence: 99%

Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique

Nacarapa¹,

Munyangaju²,

Osório

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The Pictor Plus Portable Ophthalmic Camera (Volk Optical Inc., Mentor, OH) has made it easier to capture high-resolution images of the retina for the diagnosis of conditions like diabetic retinopathy and glaucoma, particularly in locations where more sophisticated equipment is unavailable (Figure H). , Additionally, Portable X-ray Devices, such as the HF120/60HPPWV PowerPlus (MinXray, Northbrook, IL), are now accessible to field hospitals, sports medicine, and veterinary practice, as they are highly portable, lightweight, and robust. , An AI-driven image interpretation system has also been developed to complement the device use. In a study conducted in remote populations in Nigeria, an ultraportable X-ray device was used along with the AI interpretation to screen patients for tuberculosis .…”

Section: Technological Advances For Mobile Diagnostic Clinicsmentioning

confidence: 99%

“… 101 , 102 Additionally, Portable X-ray Devices, such as the HF120/60HPPWV PowerPlus (MinXray, Northbrook, IL), are now accessible to field hospitals, sports medicine, and veterinary practice, as they are highly portable, lightweight, and robust. 103 , 104 An AI-driven image interpretation system has also been developed to complement the device use. In a study conducted in remote populations in Nigeria, an ultraportable X-ray device was used along with the AI interpretation to screen patients for tuberculosis.…”

Section: Technological Advances For Mobile Diagnostic Clinicsmentioning

confidence: 99%

Mobile Diagnostic Clinics

Baron,

Haick

2024

ACS Sens.

View full text Add to dashboard Cite

This article reviews the revolutionary impact of emerging technologies and artificial intelligence (AI) in reshaping modern healthcare systems, with a particular focus on the implementation of mobile diagnostic clinics. It presents an insightful analysis of the current healthcare challenges, including the shortage of healthcare workers, financial constraints, and the limitations of traditional clinics in continual patient monitoring. The concept of “Mobile Diagnostic Clinics” is introduced as a transformative approach where healthcare delivery is made accessible through the incorporation of advanced technologies. This approach is a response to the impending shortfall of medical professionals and the financial and operational burdens conventional clinics face. The proposed mobile diagnostic clinics utilize digital health tools and AI to provide a wide range of services, from everyday screenings to diagnosis and continual monitoring, facilitating remote and personalized care. The article delves into the potential of nanotechnology in diagnostics, AI’s role in enhancing predictive analytics, diagnostic accuracy, and the customization of care. Furthermore, the article discusses the importance of continual, noninvasive monitoring technologies for early disease detection and the role of clinical decision support systems (CDSSs) in personalizing treatment guidance. It also addresses the challenges and ethical concerns of implementing these advanced technologies, including data privacy, integration with existing healthcare infrastructure, and the need for transparent and bias-free AI systems.

show abstract

“…However, radiographs are often inadequate for making the diagnosis of PTB because they have poor sensitivity for detecting mediastinal and hilar lymphadenopathy and have little specificity in characterizing parenchymal and pleural lesions [ 1 , 7 , 8 , 9 ]. CT remains the gold standard for the radiological diagnosis of PTB; it can define early features of TB (lymphadenopathy, nodules, small pleural effusion) before these become detectable in CXR [ 7 , 8 , 9 , 10 ]. However, CXR and especially CT cannot be used routinely and repeatedly in children for obvious reasons of radiation protection [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, CXR and especially CT cannot be used routinely and repeatedly in children for obvious reasons of radiation protection [ 11 ]. Moreover, they are expensive tools and their availability is limited in high TB-burden countries, low-resource settings, due to scarcity of both equipment and skilled radiological staff to perform and read the images [ 10 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Utility and Limits of Lung Ultrasound in Childhood Pulmonary Tuberculosis: Lessons from a Case Series and Literature Review

Morello¹,

Ferrari²,

Valentini³

et al. 2022

JCM

View full text Add to dashboard Cite

Childhood pulmonary tuberculosis (PTB) diagnosis is often a challenge that requires a combination of history, clinical, radiological, immunological and microbiological findings. Radiological diagnosis is based today on the use of chest X-ray and chest CT that, in addition to being radio-invasive tools for children, are often not available in countries with low-resources. A non-invasive, easily usable and reproducible, low-cost diagnostic tool as LUS would therefore be useful to use to support the diagnosis of childhood PTB. Data on the use of LUS for the diagnosis and follow-up of childhood PTB are limited and in some respects contradictory. To help better define the potential role of LUS we have described the pros and cons of lung ultrasound method through a brief review of the studies in the literature and reporting some case series in which we describe clinical, laboratory, radiological results as well as detailed lung ultrasound findings of four children/adolescents with PTB.

show abstract

Imaging of Tuberculosis in Resource-Limited Settings

Cited by 3 publications

References 43 publications

Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique

Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique

Mobile Diagnostic Clinics

Utility and Limits of Lung Ultrasound in Childhood Pulmonary Tuberculosis: Lessons from a Case Series and Literature Review

Contact Info

Product

Resources

About