Imaging of the malignant peripheral nerve sheath tumour with emphasis οn ultrasonography: correlation with MRI

Rafailidis, Vasileios; Kaziani, Theodora; Theocharides, Costas; Papanikolaou, Athanasios; Rafailidis, Dimitrios

doi:10.1007/s40477-014-0097-2

Cited by 15 publications

(15 citation statements)

References 12 publications

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“…Redzepagic et al [ 5 ] reported a case in the breast, which is a rare location for MPNST. Rafailidis et al [ 6 ] believe that MPNST typically affects major nerve trunks like the sciatic nerve, the brachial plexus, and the sacral plexus. However, in our group, except for two retroperitoneal tumors, all MPNSTs developed superficially and had no direct connection with these major nerve trunks.…”

Section: Discussionmentioning

confidence: 99%

“…However, in our group, except for two retroperitoneal tumors, all MPNSTs developed superficially and had no direct connection with these major nerve trunks. MPNST usually affects patients in 20 to 50 years old, without gender predilection [ 6 ]. It occurs more often in association with NF-1 and leads to poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…X-ray examination has limitations except that mammography can be used for tumor in the breast [ 5 ]. Ultrasonography is an easy, cost-effective, and repeatable modality [ 6 ] but unsuitable for deeply located lesion, i.e., in the retroperinum and spine canal. PET/CT allows for sensitive whole-body scan for metastasis but lack of specificity.…”

Section: Introductionmentioning

confidence: 99%

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Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

Yu¹,

Wu²,

Ye³

et al. 2016

World J Surg Onc

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BackgroundMalignant peripheral nerve sheath tumor (MPNST) is a kind of rare neurogenic tumor. If associated with neurofibromatosis type 1, MPNST usually has a higher mortality. The aim of the article is to assess the imaging characteristics of MPNST and compare them with those of benign peripheral nerve sheath tumor (BPNST) to characterize this tumor.MethodsClinical and imaging data of six cases with MPNST and 28 cases with BPNST in our institution since 2011 were retrospectively reviewed. Thirty-three patients have available MR imaging data, and two patients of MPNST also accepted CT scan. One patient accepted CT scan only. Location, size, shape, signal or density, boundary, bone destruction, relation to adjacent nerve, contrast-enhanced features as well as some other signs were assessed and compared with statistical software. Student’s t test was used for comparison of continuous variables. Fisher’s exact test was used for analysis of nominal variable. A P value ≤0.05 was considered to be statistically significant.ResultsDifferences existed between two groups in tumor size ((7.2 ± 3.3)cm in MPNST vs. (3.8 ± 1.4)cm in BPNST), unclear margin (4/6 in MPNST vs. 1/28 in BPNST), eccentricity to the nerve (1/6 in MPNST vs. 21/28 in BPNST), intratumoral lobulation (4/6 in MPNST vs. 2/28 in BPNST), peritumoral edema (3/6 in MPNST vs. 0 in BPNST), and peripheral enhancement (4/6 in MPNST (three of five MR, one CT) vs. 4/28 in BPNST). Bone destruction was observed in one MPNST.ConclusionsMR imaging is a valuable, non-invasive modality for the diagnosis of MPNST. Peripheral enhancement with non-cystic appearance or remarkable heterogeneous enhancement may be useful for differential diagnosis. Other imaging features such as large size (over 5 cm in diameter), ill-defined margin, intratumoral lobulation, peritumoral edema, and adjacent bone destruction are also supportive of MPNST.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

Yu¹,

Wu²,

Ye³

et al. 2016

World J Surg Onc

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“…73 They commonly involve major nerves and nerve trunks such as the sciatic, sacral, or brachial plexus. 75 Cranial nerve involvement and intraosseous lesions are rare. 64,76,77 Benign Malignant MPNST should be suspected when there is a rapid increase in the size of a stable neurofibroma, development of pain, or neurology.…”

Section: Malignant Peripheral Nerve Sheath Tumormentioning

confidence: 99%

Imaging of Pediatric Soft Tissue Tumors and Tumor-like Conditions

Al-Qassab

Lalam

Botchu

et al. 2021

Semin Musculoskelet Radiol

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Lumps and bumps are frequently seen in children, and the vast majority are a result of trauma, infection, or inflammation. True soft tissue neoplastic lesions are rare; however, their wide and complex classifications make these lesions challenging to manage. Imaging features are usually nonspecific, and a reasonable list of differential diagnoses can be generated following consideration of the clinical presentation, age, and anatomical location of the lesion. In this article, we offer a practical approach to diagnosing such lesions by discussing the most common three benign and malignant lesions in different anatomical regions stratified by age with emphasis on certain features that might aid in the diagnosis such as depth, multiplicity, calcification, or other specific imaging feature.

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“…Ultrasound and computed tomography (CT) can also be of value in select patients and may be used for image-guided biopsies. 12 Furthermore, bone scintigraphy may be useful to evaluate for osseous involvement. 13 Over recent years, PET has been gaining increasing traction in the assessment of musculoskeletal tumors.…”

Section: Introductionmentioning

confidence: 99%

PET Imaging of Peripheral Nerve Tumors

et al. 2019

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Malignant peripheral nerve sheath tumors (MPNST) are the sixth most frequent soft tissue sarcoma (STS), consisting of 5% to 10% of cases. Traditionally, MR imaging has been the main imaging modality to evaluate the extent and involvement of MPNT. The potential value of PET and PET/CT in regards to diagnosis, biopsy guidance, staging, and therapy response of MPNT are presented in the literature. Multimodality imaging with multiparametric hybrid PET/MR has also shown some utility in the management of peripheral nerve tumors (PNTs). Quantitative FDG-PET imaging used in combination with CT or MR imaging has shown great potential to discriminate benign from malignant PNTs.

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Imaging of the malignant peripheral nerve sheath tumour with emphasis οn ultrasonography: correlation with MRI

Cited by 15 publications

References 12 publications

Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

Imaging of Pediatric Soft Tissue Tumors and Tumor-like Conditions

PET Imaging of Peripheral Nerve Tumors

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