Imaging of Synovial Inflammation in Osteoarthritis, From the <i>AJR</i> Special Series on Inflammation

Thoenen, Jacob; Mackay, James; Sandford, Halston J C; Gold, Garry E.; Kogan, Feliks

doi:10.2214/ajr.21.26170

Cited by 17 publications

(10 citation statements)

References 81 publications

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“…However, these results' metabolic activity are not harmful to Rapamycin-loaded NPs compared to Rapamycin solution for several reasons: i) detrimental effects as cellular death was observed only with the highest concentration (100 µM) like for Rapamycin solution as explained previously; ii) chondrocytes could be protected in vivo thanks to 3D conformation and extracellular matrix production; iii) effect on synoviocytes could be compared to synoviorthesis (medical/chemical synovectomy) that have demonstrated beneficial effects in the past for inflammatory synovitis (Karavida and Notopoulos, 2010), preeminent in OA flares (Lambert et al, 2020) and during its early stages (Mathiessen and Conaghan, 2017;Thoenen et al, 2021). According to our data, we finally confirmed 10 μM Rapamycin's safety for the i.a.…”

Section: Mitochondrial Activitymentioning

confidence: 84%

Rapamycin-loaded Poly(lactic-co-glycolic) acid nanoparticles: Preparation, characterization, and in vitro toxicity study for potential intra-articular injection

Pape

Parent

Pinzano

et al. 2021

International Journal of Pharmaceutics

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Section: Mitochondrial Activitymentioning

confidence: 84%

Rapamycin-loaded Poly(lactic-co-glycolic) acid nanoparticles: Preparation, characterization, and in vitro toxicity study for potential intra-articular injection

Pape

Parent

Pinzano

et al. 2021

International Journal of Pharmaceutics

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“…Synovitis occurs in more than 50% of early OA patients [ 33 , 48 ]. It is linked to a higher risk of cartilage damage, thus worsening the disease, and correlates with an increase in pain sensation [ 120 , 123 , 124 , 125 , 126 , 127 ]. According to arthroscopic and soft tissue ultrasound (US) examination data, synovitis, confirmed by these imaging methods, is seen before OA is revealed in conventional radiographs and cartilage damage is present in magnetic resonance imaging (MRI) [ 120 , 128 ].…”

Section: Pathological Changes In Oa-affected Joint Tissuesmentioning

confidence: 99%

Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk

Semenistaja

Skuja

Kadisa

et al. 2023

IJMS

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Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint disease that is recognized as the most common type of arthritis. During the last decade, it shows an incremental global rise in prevalence and incidence. The interaction between etiologic factors that mediate joint degradation has been explored in numerous studies. However, the underlying processes that induce OA remain obscure, largely due to the variety and complexity of these mechanisms. During synovial joint dysfunction, the osteochondral unit undergoes cellular phenotypic and functional alterations. At the cellular level, the synovial membrane is influenced by cartilage and subchondral bone cleavage fragments and extracellular matrix (ECM) degradation products from apoptotic and necrotic cells. These “foreign bodies” serve as danger-associated molecular patterns (DAMPs) that trigger innate immunity, eliciting and sustaining low-grade inflammation in the synovium. In this review, we explore the cellular and molecular communication networks established between the major joint compartments—the synovial membrane, cartilage, and subchondral bone of normal and OA-affected joints.

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“…45 In the B-mode, synovitis manifests as an abnormally thickened, hypoechoic, or anechoic, which is nondisplaceable and poorly compressible (Figure 3A). 46 In the presence of active inflammation, the power/color Doppler modes of MSUS can visualize hyperemia of the intra-articular synovium (Figure 3B).…”

Section: Cartilage-bone Interfacementioning

confidence: 99%

An Update on Clinical Utility of Musculoskeletal Ultrasonography in Knee Osteoarthritis

Liu

Zhang

et al. 2023

J of Ultrasound Medicine

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In knee osteoarthritis (KOA), timely and accurate assessment of the severity is essential to help orthopedic surgeons determine the most appropriate therapeutic strategies and evaluate disease outcomes and responses for corresponding treatments. In KOA, musculoskeletal ultrasonography (MSUS) could effectively help detect various abnormalities, including synovitis, osteophytes, and cartilage damage. Further, MSUS could be used to monitor the response to different therapies in KOA, to guide local diagnostic and therapeutic procedures. In the future, applications based on continuously evolving US tools could enhance the clinical utility of MSUS in KOA.

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Imaging of Synovial Inflammation in Osteoarthritis, From the AJR Special Series on Inflammation

Cited by 17 publications

References 81 publications

Rapamycin-loaded Poly(lactic-co-glycolic) acid nanoparticles: Preparation, characterization, and in vitro toxicity study for potential intra-articular injection

Rapamycin-loaded Poly(lactic-co-glycolic) acid nanoparticles: Preparation, characterization, and in vitro toxicity study for potential intra-articular injection

Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk

An Update on Clinical Utility of Musculoskeletal Ultrasonography in Knee Osteoarthritis

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