Imaging of ^99mTc-DMSA and ¹⁸F-FDG in humans using a Si/CdTe Compton camera

Abstract

The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon/cadmium telluride (Si/CdTe) Compton camera to simultaneously image the distributions of technetium (99mTc)-dimercaptosuccinic acid (DMSA) (141 keV emission) and 18F-fluorodeoxyglucose (FDG) (511 keV emission) injected into a human volunteer. 99mTc-DMSA and 18F-FDG were injected intravenously into a 25-year-old male volunteer. The distributions of 99mTc-DMSA and 18F-FDG were simultaneously made visible by setting a specified energy window for each radioisotope. The images of these radiopharmaceuticals acquired using the prototype Compton camera were superimposed onto computed tomography images for reference. The reconstructed image showed that 99mTc-DMSA had accumulated in both kidneys, which is consistent with the well-known diagnostic distribution determined by clinical imaging via single-photon emission computed tomography. In the 18F-FDG image, there is broad distribution around the liver and kidneys, which was expected based on routine clinical positron emission tomography imaging. The current study demonstrated for the first time that the Si/CdTe Compton camera was capable of simultaneously imaging the distributions of two radiopharmaceuticals, 99mTc-DMSA and 18F-FDG, in a human body. These results suggest that the Si/CdTe Compton camera has the potential to become a novel modality for nuclear medical diagnoses enabling multi-probe simultaneous tracking.

Use of a Si/CdTe Compton Camera for In vivo Real-Time Monitoring of Annihilation Gamma Rays Generated by Carbon Ion Beam Irradiation

“…A Compton camera is a compact (i.e., ∼44.5 × 34.0 × 23.5 cm in size) device that can detect multiple radionuclides exhibiting a wide energy range (from a few hundred keV up to few MeV) simultaneously. These features indicate the device's potential for applications in medical imaging (6)(7)(8)(9)(10)(11)(12)(13).…”

Fusion-Based Neutron Generator Production of Tc-99m and Tc-101: A Prospective Avenue to Technetium Theranostics

“…The potential impact that neutron generator-produced 99 Mo/ 99m Tc and 101 Mo/ 101 Tc can have on the future of both diagnostic and theranostic modalities is considered. Whereas 99m Tc is typically considered a purely diagnostic isotope [ 15 ], it is envisioned that 101 Tc (t 1/2 = 14.22 min) could be applied as an ephemeral theranostic agent; a beta emission (~487 keV, 90.3% [ 16 ]) for radiotherapeutics is complemented by a 307 keV (89.4%) gamma emission ideal for synchronised diagnostic scanning [ 17 ]. In addition, the 99m Tc/ 101 Tc pair may be useful in dual imaging modalities [ 18 ], where the similar chemistry, but differing nuclear properties of the two isotopes could be exploited.…”

Performance demonstration of a hybrid Compton camera with an active pinhole for wide-band X-ray and gamma-ray imaging

“…They succeeded in realizing the triple gamma (i.e., PET/Compton) imaging of Sc, which emits 511 keV and 1,157 keV gamma rays; however, the application to imaging SPECT tracer remains to be researched in the future. In this context, the simultaneous capture of SPECT and PET images has also been reported using a Compton camera consisting of Si/CdTe semiconductors, which is, however, limited both in terms of detection efficiency and angular resolution 11 – 13 . We argue that such difficulties can be easily overcome with the hybrid camera proposed in this paper.…”