Imaging of Severe Traumatic Brain Injury in the Neurointensive Care Unit

Sørensen, Leif Hovgaard; Moen, Kent Gøran

doi:10.1007/978-3-030-39383-0_49

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Dealing with lesions in advanced MRI analyses is a huge challenge in TBI research in general (Olsen et al, 2020), and no single neuroimaging method is sufficient for full characterization and phenotyping of TBI (Amyot et al, 2015). Future studies may benefit from integrating information from a wider range of clinical MRI sequences such as fluid attenuated inversion recovery (FLAIR) and susceptibility weighted imaging (SWI) in order to more precisely capture acute and subacute pathology (Sørensen & Moen, 2020). Moreover, our study focused on TBM based measures of brain structure.…”

Section: Discussionmentioning

confidence: 99%

Regional Brain Volume Prior to Treatment Is Linked to Outcome after Cognitive Rehabilitation in Traumatic Brain Injury

Olsen¹,

Dennis²,

Stubberud³

et al. 2022

Preprint

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Cognitive rehabilitation is useful for many after traumatic brain injury (TBI), but we lack critical knowledge about which patients benefit the most from different approaches. Advanced neuroimaging techniques have provided important insight into brain pathology and systems plasticity after TBI and have potential to inform new practices in cognitive rehabilitation. In this study, we aimed to identify candidate structural brain measures with relevance for rehabilitation of cognitive control (executive) function after TBI. Twenty-eight patients (9 female, mean age 40.5 (SD = 13.04) years) with moderate/severe TBI (>21 months since injury) that participated in a randomized controlled cognitive rehabilitation trial (NCT02692352) were included in the analyses. Regional brain volume was extracted from T1-weighted MRI scans before treatment using tensor-based morphometry. Both positive and negative associations between treatment outcome (everyday cognitive control function) and regional brain volume were observed. The most robust structural brain measures with relevance for improvement in function were observed in midline fronto-parietal regions, including the anterior and posterior cingulate cortices. The study pro-vides proof of concept and valuable insight for planning future studies focusing on neuroimaging in cognitive rehabilitation after TBI.

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Section: Discussionmentioning

confidence: 99%

Regional Brain Volume Prior to Treatment Is Linked to Outcome after Cognitive Rehabilitation in Traumatic Brain Injury

Olsen¹,

Dennis²,

Stubberud³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Dealing with lesions in advanced MRI analyses is a huge challenge in TBI research in general ( Olsen et al, 2021 ), and no single neuroimaging method is sufficient for full characterization and phenotyping of TBI ( Amyot et al, 2015 ). Future studies may benefit from integrating information from a wider range of clinical MRI sequences such as fluid attenuated inversion recovery (FLAIR) and susceptibility weighted imaging (SWI) in order to more precisely capture acute and subacute pathology ( Sørensen & Moen, 2020 ). Moreover, our study focused on TBM based measures of brain structure.…”

Section: Discussionmentioning

confidence: 99%