Imaging of salivary gland tumours

Thoeny, Harriet C.

doi:10.1102/1470-7330.2007.0008

Cited by 167 publications

(132 citation statements)

References 35 publications

(36 reference statements)

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“…These features are, in aggregate, different from those in other common primary malignant tumors of the salivary glands, including mucoepidermoid carcinoma and adenoid cystic carcinoma because these more common malignant tumors typically show heterogeneous attenuation or signal intensity with cystic change and necrosis. [17][18][19] Thus, an ill-defined or partially ill-defined mass without cystic regions or calcification and lacking necrosis is typically seen in salivary gland LEC. In our cases, salivary gland LECs could be classified into 3 morphologic types on the basis of the margin and shape.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelial Carcinoma of the Salivary Gland: Morphologic Patterns and Imaging Features on CT and MRI

Ban

et al. 2014

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

Lymphoepithelial Carcinoma of the Salivary Gland: Morphologic Patterns and Imaging Features on CT and MRI

Ban

et al. 2014

American Journal of Neuroradiology

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“…5,7,17,21,22 However, this modality results in considerable overlap between benign and malignant tumours in terms of imaging appearance. 3 Christe et al 22 recently reported that the sensitivity and the specificity of the above-mentioned MRI findings in predicting malignancy were 70% and 73%, respectively. As a result, the validity of conventional MRI in the differential diagnosis of salivary gland tumours is considered to be limited.…”

Section: Discussionmentioning

confidence: 99%

“…Among various imaging techniques, MRI is now the modality of choice for evaluation of suspected salivary gland tumours. 3,4 Owing to its superb contrast resolution and multiplanar facilities, MRI can clearly identify a tumour's exact location and extent, as well as its relationship with neighbouring structures. On the other hand, the sensitivity of conventional MRI in predicting malignancy is known to be quite low.…”

Section: The Authors Phong Dai Lam and Ami Kuribayashi Equally Contrimentioning

confidence: 99%

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Lam¹,

Kuribayashi²,

Imaizumi³

et al. 2015

BJR

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The authors Phong Dai Lam and Ami Kuribayashi equally contributed to this work.Objective: To determine the optimal diagnostic criterion of dynamic contrast-enhanced MRI (DCE-MRI) for predicting salivary gland malignancy using a dynamic sequence with high temporal resolution, as well as the accuracy of this technique. Methods: The DCE-MRI findings of 98 salivary gland tumours (74 benign and 24 malignant) were reviewed. MR images were sequentially obtained at 5-s intervals for 370 s. Two parameters, peak time and washout ratio (WR) were determined from the time-signal intensity curve. The optimal thresholds of these parameters for differentiating benign and malignant tumours were determined, along with the diagnostic accuracy of the criterion using these thresholds. Results: A peak time of 150 s and a WR of 30% were identified as optimal thresholds. As the criterion for malignancy, the combination of peak time ,150 s and WR ,30% provided a sensitivity of 79% (19/24), specificity of 95% (70/74) and an overall accuracy of 91% (89/98). Three of the five false-negative cases were malignant lymphomas of the parotid gland. Conclusion: Peak time ,150 s with WR ,30% comprised the optimal diagnostic criterion in predicting salivary gland malignancy, providing a sensitivity of 79% and specificity of 95%. The use of high temporal resolution might improve the accuracy of DCE-MRI. Advances in knowledge: Although several studies have reported the usefulness of DCE-MRI in the differential diagnosis of salivary gland tumours, the specific diagnostic criteria employed have differed widely. We determined the optimal criterion and its accuracy using a dynamic sequence with high temporal resolution.

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“…These characteristics can also be displayed in some benign tumors as well. Other characteristics of WTs include multiple and bilateral lesions, well-circumscribed partly cystic, partly solid lesions in CT or MRI and are often located in the tail of the parotid gland (Thoeny 2007). These features should not be considered specific characteristics associated with WTs, although some of them were present in both of our patients.…”

Section: Discussionmentioning

confidence: 79%

“…Low signal intensities on T2-weighted images were shown in both patients. Because these results are linked to highly cellular tumors (Okahara et al 2003), they are sometimes reported as a representative finding for parotid malignancies (Christe et al 2011); however, they are also described as a characteristic of WTs (Thoeny 2007). In Patient 2, it should be noted that the presence of a non-encapsulated tumor and high SUV from the FDG-PET indicate malignancy.…”

Section: Discussionmentioning

confidence: 96%

Correct Diagnosis of Warthin Tumor in the Parotid Gland with Dynamic MRI

Ogawa

Suzuki

Sakamoto

et al. 2012

Tohoku J. Exp. Med.

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Warthin tumor (WT) is a benign tumor of the salivary gland primarily affecting middle-aged men. WT is almost exclusively located in the parotid gland and tend to grow slowly without symptoms. Although fine needle aspiration cytology (FNAC) often correctly diagnoses these tumors, they are occasionally misdiagnosed as malignant. Our study sought to distinguish between WT and non-WT using dynamic MRI. In dynamic MRI, a series of images are taken over time measuring the intensity of gadolinium uptake by the parotid. We examined two patients for this study. The first was a 53-year old male, heavy smoker, experiencing manic-depressive episodes. He received a brain MRI at which time his parotid tumor was discovered. Parotid FNAC indicated a squamous cell carcinoma. The second patient was a 76-year old male, moderate smoker and drinker, who had been complaining about swelling in the neck. FNAC of the parotid indicated acinic cell carcinoma and gadolinium-enhanced MRI suggested the tumor was malignant. Prior to surgically extracting of these masses, we performed dynamic MRI on each patient. Both tumors exhibited a pattern consisting of rapid enhancement and rapid attenuation, the pattern of which is characteristic of WT. The surgical specimens confirmed that both were WTs without malignant transformation. Our findings indicate that dynamic MRI is a useful tool for preoperative diagnosis of WT, where other examinations indicate malignancy. Early and correct diagnosis of WT can minimize the use of invasive procedures, and eliminate the stress placed on the patient from a diagnosis of cancer.

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Imaging of salivary gland tumours

Cited by 167 publications

References 35 publications

Lymphoepithelial Carcinoma of the Salivary Gland: Morphologic Patterns and Imaging Features on CT and MRI

Lymphoepithelial Carcinoma of the Salivary Gland: Morphologic Patterns and Imaging Features on CT and MRI

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Correct Diagnosis of Warthin Tumor in the Parotid Gland with Dynamic MRI

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