Imaging of renal cell carcinoma

Sankineni, Sandeep; Brown, Anna M.; Cieciera, Matthaeus; Choyke, Peter L.; Türkbey, Barış

doi:10.1016/j.urolonc.2015.05.020

Cited by 48 publications

(44 citation statements)

References 69 publications

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“…Gut hingegen kann die Sonographie zwischen zystischen und soliden Läsionen unterscheiden, wenn eine KM-unterstütze CT aufgrund einer KM-Allergie kontraindiziert ist [3,5].…”

Section: Cmeunclassified

“…Der CEUS hat insbesondere einen Stellenwert bei Patienten mit allergischen Reaktionen auf CT-oder MRT-KM oder Kontraindikationen zur CT und MRT [3]. Leider ist in den USA seine Anwendung durch eine bis dato nicht vorhandene Genehmigung durch die amerikanische Food and Drug Administration (FDA) eingeschränkt.…”

Section: Cmeunclassified

“…Abb. 1; [3,5]). Obwohl auch in der arteriellen Phase (15-20 s nach Applikation) darstellbar, ist die nephrographische Phase nach 70-100 s am besten geeignet, um NCC abzugrenzen [3].…”

Section: Computertomographieunclassified

“…Größere Anteile von Fett innerhalb einer Läsion deuten häufig auf ein benignes Angiomyolipom hin [3], insbesondere wenn zugleich die Sonomorphologie typisch ist -eine scharf begrenzte, echoreiche (zum Mittelecho isoechogene), evtl. keilförmige Läsion.…”

Section: Computertomographieunclassified

“…In der arteriellen Phase verbleibt das KM größtenteils in den kortikalen Kapillaren, sodass die kortikale KM-Aufnahme bei 147 ± 41 HU und die medulläre Aufnahme bei 56 ± 25 HU liegt [3]. In dieser Phase lassen sich neben der Vaskularisierung einer Läsion auch die kortikomedullären arteriellen Gefäße darstellen, was zur präoperativen Beurteilung vor einer Nierentumorresektion nützlich sein kann.…”

Section: Computertomographieunclassified

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Moderne Bildgebung von Nierentumoren – Anwendung in Diagnostik und Therapie

et al. 2016

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This article elucidates the various tools used for the diagnostics and characterization of renal lesions. The advantages and limitations of ultrasound, contrast-enhanced ultrasound (CEUS), computed tomography (CT) and magnetic resonance imaging (MRI) are presented and discussed. In addition, modern imaging features of CT and MRI, such as iodine quantification in CT as well as diffusion-weighted and perfusion imaging in MRI are presented. Lastly, recent developments in standardized reporting of renal tumors regarding the intraoperative surgical risk are presented.

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“…Gut hingegen kann die Sonographie zwischen zystischen und soliden Läsionen unterscheiden, wenn eine KM-unterstütze CT aufgrund einer KM-Allergie kontraindiziert ist [3,5].…”

Section: Cmeunclassified

“…Abb. 1; [3,5]). Obwohl auch in der arteriellen Phase (15-20 s nach Applikation) darstellbar, ist die nephrographische Phase nach 70-100 s am besten geeignet, um NCC abzugrenzen [3].…”

Section: Computertomographieunclassified

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Moderne Bildgebung von Nierentumoren – Anwendung in Diagnostik und Therapie

et al. 2016

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Transcriptome mapping of renal clear cell carcinoma revealed by machine learning algorithm based on enhanced computed tomography images

Huang

Liang

2023

The Journal of Gene Medicine

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Background: A growing number of studies have shown that inflammation-related components of the tumor microenvironment (TME) affect the clinical outcomes of cancer patients, and advances in radiomics may help predict survival and prognosis.Methods: We performed a systematic analysis of inflammation-related genes (IRGs) in clear cell renal cell carcinoma (ccRCC) from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus and mapped their interaction network to assess the specific relationship between these differentially expressed inflammation-related genes (DEIRGs) and inflammation. The association between DEIRGs and prognosis was discussed and further validated using consensus cluster analysis. Next, we constructed IRGs-related risk score from the collected information and validated the prognostic value of the model using Kaplan-Meier survival analysis and receiver operating characteristic analysis. Computed tomographic images corresponding to the TCGA-ccRCC cohort were obtained from the Cancer Imaging Archive database for radiomics signature extraction. Results:We screened for prognostic IRGs and found that they were positively correlated with inflammatory cells in the tumor microenvironment associated with tumor progression and metastasis, such as activated CD8+ cells, myeloid-derived suppressor cells and neutrophils. The impact of IRGs on the prognosis of ccRCC patients was also verified. Using these differentially expressed genes, we successfully constructed a risk signature and validated its good prognosis assessment for patients. Furthermore, radiomics-based prognostic models performed better than those using risk signatures or clinical characteristics.Conclusions: IRG-related risk scores play an important role in assessing the prognosis and improving the management of patients with ccRCC. Through this feature, the infiltration of immune cells in the TME can be predicted. Furthermore, non-invasive radiomics signatures showed satisfactory performance in predicting ccRCC prognosis.

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Diagnostic Applications of Nuclear Medicine: Kidney and Bladder Cancer

Bouchelouche

2022

Nuclear Oncology

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Imaging of renal cell carcinoma

Cited by 48 publications

References 69 publications

Moderne Bildgebung von Nierentumoren – Anwendung in Diagnostik und Therapie

Moderne Bildgebung von Nierentumoren – Anwendung in Diagnostik und Therapie

Transcriptome mapping of renal clear cell carcinoma revealed by machine learning algorithm based on enhanced computed tomography images

Diagnostic Applications of Nuclear Medicine: Kidney and Bladder Cancer

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