Imaging of radionuclide emissions with a low-noise charge-coupled device

Karellas, Andrew; Liu, H.; Reinhardt, Christopher P.; Harris, Lisa J.; Brill, A. B.

doi:10.1109/23.256696

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Introduction2

B Electronic Autoradiography1

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Cited by 25 publications

(14 citation statements)

References 6 publications

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“…An alternative approach is the application of a cooled CCD to detect the light emitted by /3-particle interactions in a scintillator (34,35). /3-Imager of Biospace Measures.…”

Section: B Electronic Autoradiographymentioning

confidence: 99%

Thin-Layer Radiochromatography

Klebovich¹,

Hazai²

2003

Handbook of Thin-Layer Chromatography

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“…An alternative approach is the application of a cooled CCD to detect the light emitted by /3-particle interactions in a scintillator (34,35). /3-Imager of Biospace Measures.…”

Section: B Electronic Autoradiographymentioning

confidence: 99%

Thin-Layer Radiochromatography

Klebovich¹,

Hazai²

2003

Handbook of Thin-Layer Chromatography

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“…[7]). Charge coupled devices (CCD) [10,11] are also used, exploiting the direct exposure and coupling to scintillators techniques, while for the latter an additional electron gain can be provided by microchannel plates (MCP) (e.g. [8,9]).…”

Section: Introductionmentioning

confidence: 99%

Tritium autoradiography with thinned and back-side illuminated monolithic active pixel sensor device

Deptuch

2005

Nuclear Instruments and Methods in Physics Research Section A:

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“…In some applications, excited light out of the scintillators is further amplified, e.g., by multiple microchannel plates, to improve sensitivity [10]–[13]. Other applications use thicker scintillators to improve excited-light production [14]–[16]. …”

Section: Introductionmentioning

confidence: 99%

Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications

Chen

Gobar

Knowles

et al. 2009

IEEE Trans. Nucl. Sci.

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Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper [1], we reported a newly developed system capable of directly imaging highenergy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal 18 F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.

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Imaging of radionuclide emissions with a low-noise charge-coupled device

Cited by 25 publications

References 6 publications

Thin-Layer Radiochromatography

Thin-Layer Radiochromatography

Tritium autoradiography with thinned and back-side illuminated monolithic active pixel sensor device

Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications

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