Imaging of prehospital stroke therapeutics

Lin, Michelle; Sanossian, Nerses; Liebeskind, David S

doi:10.1586/14779072.2015.1075882

Cited by 11 publications

(9 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stroke is a serious medical and social problem, and despite the existing therapy, too few patients qualify to the proposed treatment. Only 15-60% of patients with stroke are admitted to the hospital within 3 hours after the onset of symptoms, and even less within 2 hours, when the intravenous thrombolysis is the most effective [16,17]. Extending the time window is associated with the use of thrombectomy; in the light of recent studies for the selection of patients with ischemic stroke based on imaging for reperfusion therapy, the time window of mechanical thrombectomy may be prolonged by 6-8 hours [9], according to some authors even up to 24 hours (or longer) from the onset of symptoms [18,19].…”

Section: Discussionmentioning

confidence: 99%

Endovascular and Thrombolytic Therapy and the Functional Status of Patients after Ischemic Stroke

Jabłońska

Wronkowska

Ślusarz

et al. 2019

PNIN

View full text Add to dashboard Cite

Introduction. Stroke is treated as a direct threat to life. Mechanical thrombectomy used as an independent treatment or in combination with systemic thrombolysis is currently the standard care in the treatment of ischemic stroke. Aim. Evaluation of the functional status of patients after ischemic stroke treated with thrombolysis or thrombectomy. Material and Methods. The study involved 50 patients hospitalized due to ischemic stroke. Standardized research tools were used: the Rankin scale, the Barthel scale and the Functional Index "Repty" (WFR). The study was conducted twice in one patient: on the first and ninth day after the treatment. The collected material was developed statistically. Results. Most of the respondents were men-62%. Thrombolytic treatment was used in all subjects, and thrombectomy in 26% people. Analyses showed that there were differences in the Barthel scale level Z = 4.87; p < 0.001, Rankin Z = 4.80; p < 0.001 and WFR Z = 4.83; p < 0.001. The age of the respondents was related negatively to the Barthel scale score on the 1 st day ρ =-0.51; p < 0.001 and the 9 th day ρ =-0.53; p < 0.001 and the result in the WFR scale on the 1 st day ρ =-0.54; p < 0.001 and the 9 th day ρ =-0.52; p < 0.001. Conclusions. The performance of the subjects on the 1st day of treatment was worse than on the 9th day. People who were only treated with thrombolysis had better results in fitness tests and had a lower level of disability than people treated with thrombolysis and thrombectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Endovascular and Thrombolytic Therapy and the Functional Status of Patients after Ischemic Stroke

Jabłońska

Wronkowska

Ślusarz

et al. 2019

PNIN

View full text Add to dashboard Cite

show abstract

“…Pre-hospital assessment based upon symptom checklists alone creates substantial inefficiencies for stroke patients (treatment delays), mimics (displacement to specialist units) and services (additional demands on resources). However, improvement in early stratification/ diagnosis of stroke and LVO/ICH subgroups may be possible with emerging technologies which are deployable in standard ambulances [13]. Many are still at early stages of development and will require evaluation of feasibility and resource impact relative to their ability to differentiate, individually or in combination, between key subgroups during the first few hours after symptom onset [14].…”

Section: Introductionmentioning

confidence: 99%

A scoping review of pre-hospital technology to assist ambulance personnel with patient diagnosis or stratification during the emergency assessment of suspected stroke

et al. 2020

View full text Add to dashboard Cite

Background: Pre-hospital identification of key subgroups within the suspected stroke population could reduce delays to emergency treatment. We aimed to identify and describe technology with existing proof of concept for diagnosis or stratification of patients in the pre-hospital setting. Methods: A systematic electronic search of published literature (from 01/01/2000 to 06/06/2019) was conducted in five bibliographic databases. Two reviewers independently assessed eligibility of studies or study protocols describing diagnostic/stratification tests (portable imaging/biomarkers) or technology facilitating diagnosis/ stratification (telemedicine) used by ambulance personnel during the assessment of suspected stroke. Eligible descriptions required use of tests or technology during the actual assessment of suspected stroke to provide information directly to ambulance personnel in the pre-hospital setting. Due to study, intervention and setting heterogeneity there was no attempt at meta-analysis.

show abstract

“…Among the existing methods of treating ischemic stroke, thrombolytic therapy that aims at fast restoration of cerebral blood flow is generally recognized (20). However, despite the proven effectiveness of thrombolytic pharmacotherapy, this pharmacological approach has significant limitations for use (such as a small therapeutic window); In addition, there is a significant risk of reperfusion complications of thrombolytic therapy (21). It is important that measures used to prevent ischemic stroke are focused on reducing the impact of risk factors (hypreglycemia, atherosclerosis, coronary heart disease) on the human body, or limited to the use of dietary supplements of cerebrotropic action, which often have little evidence of use (22).…”

Section: Discussionmentioning

confidence: 99%

Administration of 4-Hydroxy-3,5-Di-Tertbutyl Cinnamic Acid Restores Mitochondrial Function in Rabbits with Cerebral Ischemia

Pozdnyakov

Hadzhieva

Pozdnyakova

2022

Serbian Journal of Experimental and Clinical Research

View full text Add to dashboard Cite

The aim of the study is to evaluate the effect of 4-hydroxy-3,5- di-tertbutyl cinnamic acid on the change in mitochondrial function under conditions of experimental cerebral ischemia in rabbits. The study was performed on 48 male rabbits, which were used for modeling permanent cerebral ischemia by occlusion of the common carotid arteries. The test compound was administered before modeling ischemia for 14 days and after the occurrence of reproducing ischemia, in a similar time interval. After that, neurological deficit and the parameters of mitochondrial respiration, the intensity of anaerobic processes, the latent opening time of the mitochondrial permeability transition pore, the value of the mitochondrial membrane potential and the concentration of caspase – 3 were determined. The administration of 100 mg/kg of 4-hydroxy-3,5-di-tertbutyl cinnamic acid into the animals reduced neurological deficit and restored the mitochondrial membrane potential. Prophylactic administration of 4-hydroxy- 3,5-di-tertbutyl cinnamic acid, contributed to an increase in ATPgenerating ability, the maximum level of respiration and respiratory capacity by 4.1 times (p<0.01), 4.8 times (p<0.01) and 4.3 times (p<0.01), respectively. With therapeutic administration, these indicators increased by 11 times (p<0.01), 12.2 times (p<0.01) and 8.6 times (p<0.01), respectively. Also, both the prophylactic and therapeutic use of 4-hydroxy-3,5-di-tret-butyl cinnamic acid normalized aerobic/anaerobic metabolism, as well as reduced the concentration of caspase-3. Based on the obtained data, significant cerebroprotective properties of 4-hydroxy-3,5- di-tertbutyl cinnamic acid can be assumed. Moreover, the potential mechanism of action of this compound may be mediated by the normalization of mitochondrial function.

show abstract

Imaging of prehospital stroke therapeutics

Cited by 11 publications

References 129 publications

Endovascular and Thrombolytic Therapy and the Functional Status of Patients after Ischemic Stroke

Endovascular and Thrombolytic Therapy and the Functional Status of Patients after Ischemic Stroke

A scoping review of pre-hospital technology to assist ambulance personnel with patient diagnosis or stratification during the emergency assessment of suspected stroke

Administration of 4-Hydroxy-3,5-Di-Tertbutyl Cinnamic Acid Restores Mitochondrial Function in Rabbits with Cerebral Ischemia

Contact Info

Product

Resources

About