Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT

Pircher, Michael; Götzinger, Erich; Leitgeb, Rainer A.; Sattmann, Harald; Findl, Oliver; Hitzenberger, Christoph K.

doi:10.1364/opex.12.005940

Cited by 127 publications

(109 citation statements)

References 30 publications

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“…Recently, a report was published that showed the use of FD OCT to create volumetric representations of various macular lesions, which is an extension of the technique we have illustrated in this article. 16 Other reports have been published which demonstrate similar mapping techniques using time-domain OCT. 17,18,28 In those time-domain models, however, the map was created from a series of C-scans, a potential weakness of which is that most clinicians rely on B-scans for evaluation of the retina. Therefore, high-quality B-scans are more desirable than C-scans.…”

Section: Discussionmentioning

confidence: 99%

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

et al. 2006

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Purpose: To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology.Design: Prospective observational case series. Participants: Five patients with a variety of macular pathologies. Methods: Patients were imaged with a Fourier-domain high-speed high-resolution OCT system built at our institution. A sweeping serial OCT B-scan of the macula was acquired to create a detailed retinal structural map. The data were then used to make individual clinical observations.Results: Rapid serial OCT B-scans produced detailed macular maps for all 5 patients. Diagnoses of imaged patients included macular hole, lamellar macular hole, regressed macular hole or macular microhole, choroidal neovascular membrane (CNV) from age-related macular degeneration, and CNV from presumed ocular histoplasmosis syndrome. Reconstructed B-scans and C-scans are shown for selected patients to illustrate the additional perspectives gained by obtaining a detailed retinal map.Conclusions: Rapid serial Fourier-domain OCT B-scanning can be used to create a detailed retinal structural map. This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.

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Section: Discussionmentioning

confidence: 99%

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

et al. 2006

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“…Spectral domain optical coherence tomography (SDOCT) has recently emerged as a powerful new tool for noninvasive ophthalmic imaging [1][2][3][4][5][6][7][8][9][10]. Accurate determinations of corneal curvature, refractive power, and wave aberrations are important in clinical diagnosis and management.…”

Section: Introductionmentioning

confidence: 99%

3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea

Zhao¹,

Kuo²,

Izatt³

2010

Opt. Express

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Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems for accurate extraction of quantitative keratometric parameters. In this work, an SDOCT scanning protocol and motion correction algorithm were implemented to minimize the effects of patient motion during data acquisition. Procedures are described for correction of image data artifacts resulting from 3D refraction of SDOCT light in the cornea and from non-idealities of the scanning system geometry performed as a pre-requisite for accurate parameter extraction. Zernike polynomial 3D reconstruction and a recursive half searching algorithm (RHSA) were implemented to extract clinical keratometric parameters including anterior and posterior radii of curvature, central cornea optical power, central corneal thickness, and thickness maps of the cornea. Accuracy and repeatability of the extracted parameters obtained using a commercial 859nm SDOCT retinal imaging system with a corneal adapter were assessed using a rigid gas permeable (RGP) contact lens as a phantom target. Extraction of these parameters was performed in vivo in 3 patients and compared to commercial Placido topography and Scheimpflug photography systems. The repeatability of SDOCT central corneal power measured in vivo was 0.18 Diopters, and the difference observed between the systems averaged 0.1 Diopters between SDOCT and Scheimpflug photography, and 0.6 Diopters between SDOCT and Placido topography.

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“…Tissue can change the polarization state of the light by several mechanisms: birefringence [69], diattenuation [70], or polarization scrambling [71]. While early implementations of PS-OCT measured only reflectivity and phase retardation between the polarization axes [67,68], improved techniques developed in recent years can extract and image more information, such as Stokes vectors of the backscattered light [72], Müller and Jones matrix distribution [73,74], axis orientation [75], and diattenuation [70].…”

Section: Polarization Sensitive Octmentioning

confidence: 99%

“…Detecting changes caused by early stage glaucoma can improve the diagnostic accuracy. PS-OCT is also useful for a more precise delineation of different retinal layers based on their polarization properties [71,163]. For instance, the retinal pigment epithelium can be identified by its depolarizing nature, which may prove helpful for the detection and monitoring of diseases affecting this layer [164].…”

Section: Developments In Ophthalmic Octmentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT

Cited by 127 publications

References 30 publications

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea

Optical coherence tomography—current technology and applications in clinical and biomedical research

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